Evidence map›Paper›PMID 32429774›Full record

ArticleHospital practice (1995)2020

Anti-coagulant and anti-platelet therapy in the COVID-19 patient: a best practices quality initiative across a large health system.

Ryan A Watson, Drew M Johnson, Robin N Dharia, Geno J Merli, John U Doherty

Open access · greenAbstract read
In one paragraph

Article in Hospital practice (1995), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
  2. Article
  3. A systematic review on post-discharge venous thromboembolism prophylaxis in patients with COVID-19.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Review
  4. Review
  5. A comprehensive review of vascular complications in COVID-19.Journal of thrombosis and thrombolysis · 2022
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. COVID-19-Associated Cardiovascular Complications.Diseases (Basel, Switzerland) · 2021
    Review
  13. Review
  14. Review
  15. Observational
  16. Acute myocardial infarction in COVID-19 patients. A review of cases in the literature.Archives of medical sciences. Atherosclerotic diseases · 2021
    Article
  17. Thrombotic complications of COVID-19.The American journal of emergency medicine · 2021
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ryan A WatsonDivision of Cardiology, Department of Medicine, At Thomas Jefferson University Hospital, Sidney Kimmel Medical College , Philadelphia, PA, USA.ORCID https://orcid.org/0000-0003-3069-697X
Drew M JohnsonDivision of Cardiology, Department of Medicine, At Thomas Jefferson University Hospital, Sidney Kimmel Medical College , Philadelphia, PA, USA.ORCID https://orcid.org/0000-0003-4768-8183
Robin N DhariaDivision of Cerebrovascular Disease, Department of Neurology, Thomas Jefferson University Hospital, Sidney Kimmel Medical College , Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-1335-4508
Geno J MerliDivision of Vascular Medicine, Department of Surgery and Medicine, Thomas Jefferson University Hospital, Sidney Kimmel Medical College , Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-8663-6872
John U DohertyDivision of Cardiology, Department of Medicine, At Thomas Jefferson University Hospital, Sidney Kimmel Medical College , Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-5704-1335
Thomas Jefferson University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged health-care systems and physicians worldwide to attempt to provide the best care to their patients with an evolving understanding of this unique pathogen. This disease and its worldwide impact have sparked tremendous interest in the epidemiology, pathogenesis, and clinical consequences of COVID-19. This accumulating body of evidence has centered around case series and often empiric therapies as controlled trials are just getting underway. What is clear is that patients appear to be at higher risk for thrombotic disease states including acute coronary syndrome (ACS), venous thromboembolism (VTE) such as deep vein thrombosis (DVT) or pulmonary embolism (PE), or stroke. Patients with underlying cardiovascular disease are also at higher risk for morbidity and mortality if infected. These patients are commonly treated with anticoagulation and/or antiplatelet medications and less commonly thrombolysis during hospitalization, potentially with great benefit but the management of these medications can be difficult in potentially critically ill patients. In an effort to align practice patterns across a large health system (Jefferson Health 2,622 staffed inpatient beds and 319 intensive care unit (ICU) beds across 14 facilities), a task force was assembled to address the utilization of anti-thrombotic and anti-platelet therapy in COVID-19 positive or suspected patients. The task force incorporated experts in Cardiology, Vascular Medicine, Hematology, Vascular Surgery, Pharmacy, and Vascular Neurology. Current guidelines, consensus documents, and policy documents from specialty organizations were used to formulate health system recommendations.

objectiveOur goal is to provide guidance to the utilization of antithrombotic and antiplatelet therapies in patients with known or suspected COVID-19.

Indexed as

Coronavirus InfectionsPandemicsPneumonia, ViralAnticoagulantsBetacoronavirusBlood CoagulationClinical ProtocolsCOVID-19Drug InteractionsHumansIschemiaPost-Exposure ProphylaxisPractice Guidelines as TopicSARS-CoV-2ST Elevation Myocardial InfarctionStrokeAnticoagulantsacute coronary syndromeanti-coagulationanti-plateletCOVID-19extracorporeal membrane oxygenationleft ventricular assist deviceperipheral arterial diseasestrokethrombosisvenous thromboembolism

Identifiers

PMID32429774
PMCPMC7441801
OpenAlexW3025142556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.