Evidence map›Paper›PMID 32429483›Full record

ArticleCells2020

Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish.

Doris Lou Demy, Maria Letizia Campanari, Raphael Munoz-Ruiz, Heather D Durham, Benoit J Gentil, Edor Kabashi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Associations ofTranslational pediatrics · 2025
    Article
  3. Modeling of Charcot-Marie-Tooth disease in zebrafish.Frontiers in molecular neuroscience · 2025
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Doris Lou DemyInstitut Imagine, UMR-1163 INSERM et Université Paris Descartes, Hôpital Universitaire Necker-Enfants Malades, 24, boulevard du Montparnasse, 75015 Paris, France.
Maria Letizia CampanariInstitut Imagine, UMR-1163 INSERM et Université Paris Descartes, Hôpital Universitaire Necker-Enfants Malades, 24, boulevard du Montparnasse, 75015 Paris, France.
Raphael Munoz-RuizInstitut Imagine, UMR-1163 INSERM et Université Paris Descartes, Hôpital Universitaire Necker-Enfants Malades, 24, boulevard du Montparnasse, 75015 Paris, France.
Heather D DurhamDepartment of Neurology and Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Benoit J GentilDepartment of Neurology and Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Edor KabashiInstitut Imagine, UMR-1163 INSERM et Université Paris Descartes, Hôpital Universitaire Necker-Enfants Malades, 24, boulevard du Montparnasse, 75015 Paris, France.
Centre National de la Recherche Scientifique · FRHôpital Necker-Enfants Malades · FRMcGill University · CAMontreal Neurological Institute and Hospital · CAUniversité Paris Cité · FR

Funding

CIHR
6 · The paper itself

Abstract

Neurofilaments (NFs), a major cytoskeletal component of motor neurons, play a key role in the differentiation, establishment and maintenance of their morphology and mechanical strength. The de novo assembly of these neuronal intermediate filaments requires the presence of the neurofilament light subunit (NEFL), whose expression is reduced in motor neurons in amyotrophic lateral sclerosis (ALS). This study used zebrafish as a model to characterize the NEFL homologue

Indexed as

AnimalsAtrophyAxonsCell LineDNA-Binding ProteinsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalHumansMotor ActivityMotor NeuronsNeurofilament ProteinsPhenotypePolymerizationPostural BalanceRNA SplicingSequence Homology, Amino AcidDNA-Binding Proteinsneflb protein, zebrafishNeurofilament ProteinsTardbp protein, zebrafishZebrafish Proteinsamyotrophic lateral sclerosis (ALS), neurofilament light (NEFL), TDP-43neurofilaments (NFs)zebrafish

Identifiers

PMID32429483
PMCPMC7291018
OpenAlexW3024579974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.