Evidence map›Paper›PMID 32429480›Full record

ArticleJournal of clinical medicine2020

Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT.

Jose Javier Garcia-Medina, Monica Del-Rio-Vellosillo, Ana Palazon-Cabanes, Maria Dolores Pinazo-Duran, Vicente Zanon-Moreno, Maria Paz Villegas-Perez

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Sectoral analysis of macular inner retinal layers and diagnostic performance in early pseudoexfoliation glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Automated macular segmentation can distinguish glaucomatous from compressive optic neuropathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Observational
  6. Macular Anatomy Differs in Dyslexic Subjects.Journal of clinical medicine · 2023
    Article
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Jose Javier Garcia-MedinaDepartment of Ophthalmology, General University Hospital Morales Meseguer, 30007 Murcia, Spain.ORCID 0000-0002-6245-7271
Monica Del-Rio-VellosilloDepartment of Anesthesiology, University Hospital Virgen de la Arrixaca, 30120 Murcia, Spain.
Ana Palazon-CabanesDepartment of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, Spain.
Maria Dolores Pinazo-DuranOphthalmic Research Unit Santiago Grisolia/FISABIO, 46017 Valencia, Spain.ORCID 0000-0002-0118-7837
Vicente Zanon-MorenoArea of Health Sciences, Valencian International University, 46002 Valencia, Spain.ORCID 0000-0003-1179-1592
Maria Paz Villegas-PerezDepartment of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, Spain.ORCID 0000-0002-5734-482X
Universitat de València · ESHospital Reina Sofía de Murcia · ESHospital Universitario Virgen de la Arrixaca · ESInstituto de Salud Carlos III · ESValencian International University · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and fifty-seven eyes of 57 early POAG patients were included. The thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform and nuclear layer, photoreceptor layer (PRL) and retinal pigment epithelium were obtained in 64 cells for each macular layer and mean thickness of superior and inferior hemispheres was also calculated. Thinning of superior and inferior hemisphere mean thickness in mRNFL, GCL and IPL and thickening of superior and inferior hemisphere mean thickness in PRL and inferior hemisphere in INL were found in early GPAA group. Otherwise, heatmaps representing cell-to-cell comparisons showed thinning patterns in inner retinal layers (except for INL) and thickening patterns in outer retinal layers in GPAA group. We found that 8 × 8 PPA not only allows the detection of significant thinning patterns in inner retinal layers, but also thickening patterns in outer retinal layers when comparing early POAG eyes to OHT eyes.

Indexed as

glaucomaheatmapinner retinalayermaculaocular hypertensionoptical coherence tomographyouter retinaposterior pole algorithmSpectralis

Identifiers

PMID32429480
PMCPMC7290368
OpenAlexW3024028386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.