Evidence map›Paper›PMID 32429433›Full record

ReviewMolecules (Basel, Switzerland)2020

Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets.

Sabrina Taliani, Federico Da Settimo, Claudia Martini, Sonia Laneri, Ettore Novellino, Giovanni Greco

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Novel positive allosteric modulators of AJournal of enzyme inhibition and medicinal chemistry · 2021
    Article
  9. Carbonic anhydrase activation profile of indole-based derivatives.Journal of enzyme inhibition and medicinal chemistry · 2021
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sabrina TalianiDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.ORCID 0000-0001-8675-939X
Federico Da SettimoDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.
Claudia MartiniDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.ORCID 0000-0001-9379-3027
Sonia LaneriDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano, 49, 80131 Naples, Italy.
Ettore NovellinoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano, 49, 80131 Naples, Italy.
Giovanni GrecoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano, 49, 80131 Naples, Italy.
University of Naples Federico II · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several indole derivatives have been disclosed by our research groups that have been collaborating for nearly 25 years. The results of our investigations led to a variety of molecules binding selectively to different pharmacological targets, specifically the type A γ-aminobutyric acid (GABA

Indexed as

Drug DesignAnimalsDiazepamGABA ModulatorsHumansIndolesKelch-Like ECH-Associated Protein 1LigandsMiceProtein BindingProto-Oncogene Proteins c-mdm2Receptor, Adenosine A2BReceptors, GABAReceptors, GABA-AStructure-Activity RelationshipDiazepamGABA ModulatorsIndolesKEAP1 protein, humanKelch-Like ECH-Associated Protein 1LigandsMDM2 protein, humanMdm2 protein, mouseProto-Oncogene Proteins c-mdm2Receptor, Adenosine A2BReceptors, GABAReceptors, GABA-ATSPO protein, humanA2B adenosine receptor (A2B AR)Kelch-like ECH-associated protein 1 (Keap1)murine double Minute 2 (MDM2) proteintranslocator protein (TSPO)type A γ-aminobutyric acid (GABAA) chloride channel

Identifiers

PMID32429433
PMCPMC7287756
OpenAlexW3025612536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.