Evidence map›Paper›PMID 32429416›Full record

ReviewNutrients2020

Immunomodulatory Effects of Vitamin D in Thyroid Diseases.

Chiara Mele, Marina Caputo, Alessandro Bisceglia, Maria Teresa Samà, Marco Zavattaro, Gianluca Aimaretti, Loredana Pagano, Flavia Prodam, Paolo Marzullo

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. The role of nutrition on thyroid health and disease: myths and facts.Journal of endocrinological investigation · 2026
    Review
  3. Review
  4. Frontiers in immunology · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Autoimmune Thyroiditis and Vitamin D.International journal of molecular sciences · 2024
    Review
  16. IFN-γ, IL-17, IL-22American journal of clinical and experimental immunology · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chiara MeleDepartment of Translational Medicine, University of Piemonte Orientale UPO, 28100 Novara, Italy.
Marina CaputoDepartment of Health Sciences, University of Piemonte Orientale UPO, 28100 Novara, Italy.
Alessandro BiscegliaDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Maria Teresa SamàDivision of Endocrinology, University Hospital "Maggiore della Carità", 28100 Novara, Italy.
Marco ZavattaroDivision of Endocrinology, University Hospital "Maggiore della Carità", 28100 Novara, Italy.
Gianluca AimarettiDepartment of Translational Medicine, University of Piemonte Orientale UPO, 28100 Novara, Italy.
Loredana PaganoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Flavia ProdamDepartment of Health Sciences, University of Piemonte Orientale UPO, 28100 Novara, Italy.ORCID 0000-0001-9660-5335
Paolo MarzulloDepartment of Translational Medicine, University of Piemonte Orientale UPO, 28100 Novara, Italy.ORCID 0000-0003-3215-5747
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D is a secosteroid with a pleiotropic role in multiple physiological processes. Besides the well-known activity on bone homeostasis, recent studies suggested a peculiar role of vitamin D in different non-skeletal pathways, including a key role in the modulation of immune responses. Recent evidences demonstrated that vitamin D acts on innate and adaptative immunity and seems to exert an immunomodulating action on autoimmune diseases and cancers. Several studies demonstrated a relationship between vitamin D deficiency, autoimmune thyroid disorders, and thyroid cancer. This review aims to summarize the evidences on the immunomodulatory effect of vitamin D on thyroid diseases.

Indexed as

HumansImmunologic FactorsImmunomodulationThyroid DiseasesThyroiditis, AutoimmuneVitamin DVitamin D DeficiencyImmunologic FactorsVitamin Dimmune systemthyroid autoimmunitythyroid cancervitamin D

Identifiers

PMID32429416
PMCPMC7284826
OpenAlexW3024701712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.