Evidence map›Paper›PMID 32429356›Full record

ArticleCells2020

The Influence of Palmatine Isolated from

Kinga Gawel, Wirginia Kukula-Koch, Dorota Nieoczym, Katarzyna Stepnik, Wietske van der Ent, Nancy Saana Banono, Dominik Tarabasz, Waldemar A Turski, Camila V Esguerra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
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  15. Discovery of (Journal of medicinal chemistry · 2022
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  18. 6-Gingerol, a Major Constituent ofInternational journal of molecular sciences · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Kinga GawelChemical Neuroscience Group, Faculty of Medicine, Centre for Molecular Medicine Norway, University of Oslo, Gaustadalléen 21, 0349 Oslo, Norway.
Wirginia Kukula-KochChair and Department of Pharmacognosy, Medical University of Lublin, 1, Chodzki Str. 1, 20-093 Lublin, Poland.
Dorota NieoczymDepartment of Animal Physiology and Pharmacology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka Str. 19, 20-033 Lublin, Poland.
Katarzyna StepnikDepartment of Physical Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, Pl. M. Curie-Skłodowskiej 3/243, 20-031 Lublin, Poland.
Wietske van der EntChemical Neuroscience Group, Faculty of Medicine, Centre for Molecular Medicine Norway, University of Oslo, Gaustadalléen 21, 0349 Oslo, Norway.
Nancy Saana BanonoChemical Neuroscience Group, Faculty of Medicine, Centre for Molecular Medicine Norway, University of Oslo, Gaustadalléen 21, 0349 Oslo, Norway.
Dominik TarabaszChair and Department of Pharmacognosy, Medical University of Lublin, 1, Chodzki Str. 1, 20-093 Lublin, Poland.
Waldemar A TurskiDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego Str. 8b, 20-090 Lublin, Poland.
Camila V EsguerraChemical Neuroscience Group, Faculty of Medicine, Centre for Molecular Medicine Norway, University of Oslo, Gaustadalléen 21, 0349 Oslo, Norway.
Medical University of Lublin · PLUniversity of Oslo · NOMaria Curie-Skłodowska University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Palmatine (PALM) and berberine (BERB) are widely identified isoquinoline alkaloids among the representatives of the Berberidaceae botanical family. The antiseizure activity of BERB was shown previously in experimental epilepsy models. We assessed the effect of PALM in a pentylenetetrazole (PTZ)-induced seizure assay in zebrafish, with BERB as an active reference compound. Both alkaloids were isolated from the methanolic root extract of

Indexed as

AnimalsBehavior, AnimalBerberineBerberine AlkaloidsBerberisBlood-Brain BarrierBrain-Derived Neurotrophic FactorElectroencephalographyLarvaLocomotionPentylenetetrazolePlant ExtractsProto-Oncogene Proteins c-fosQuantitative Structure-Activity RelationshipSeizuresZebrafishBerberineBerberine AlkaloidsBrain-Derived Neurotrophic FactorpalmatinePentylenetetrazolePlant ExtractsProto-Oncogene Proteins c-fosanticonvulsant activityberberineBerberis sibirica radixEEGisolationlocomotor activitypalmatinepentylenetetrazoleseizureszebrafish

Identifiers

PMID32429356
PMCPMC7290958
OpenAlexW3024008619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.