ReviewAntibiotics (Basel, Switzerland)2020
Detection of Quorum-Sensing Molecules for Pathogenic Molecules Using Cell-Based and Cell-Free Biosensors.
Review in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Modified experimental protocol to support the study of bacterial quorum sensing in higher education: an investigative activity withJournal of microbiology & biology education · 2026Article
- Isolation and Characterization of Variants of Quorum-Sensing Signal Molecules in Clinical Acinetobacter baumannii Isolates.Current microbiology · 2026Article
- Assessing of auto-inducer type-1 (AI-1) molecule N-(3-hydroxybutanoyl)-L-homoserine lactone responsible for quorum sensing mechanisms in marine pathogenic bacterium Vibrio harveyi.Archives of microbiology · 2026Article
- LC-MS/MS Determination of Quorum Sensing Molecules in Plasma from Burn Patients with Septic Shock Sustained by Acinetobacter Baumannii.Antibiotics (Basel, Switzerland) · 2025Article
- Quorum Sensing: Not Just a Bridge Between Bacteria.MicrobiologyOpen · 2025Review
- Unveiling bacterial communication with a MATLAB GUI implementing the diffusion-based quorum sensing model.Scientific reports · 2024Article
- Comprehensive insights into UTIs: from pathophysiology to precision diagnosis and management.Frontiers in cellular and infection microbiology · 2024Review
- Whole-Cell Biosensors for Qualitative and Quantitative Analysis of Quorum Sensing Signal Molecules and the Investigation of Quorum Quenching Agents.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Thermal Pyocyanin Sensor Based on Molecularly Imprinted Polymers for the Indirect Detection ofACS sensors · 2023Article
- ModifiedFrontiers in molecular biosciences · 2023Article
- Molecular Mechanisms and Applications of N-Acyl Homoserine Lactone-Mediated Quorum Sensing in Bacteria.Molecules (Basel, Switzerland) · 2022Review
- Highly Sensitive Detection of PQS Quorum Sensing in Pseudomonas Aeruginosa Using Screen-Printed Electrodes Modified with Nanomaterials.Biosensors · 2022Article
- Consequence of COVID-19 occurrences in wastewater with promising recognition and healing technologies: A review.Environmental progress & sustainable energy · 2022Review
- Transcription Factor-Based Biosensors for Detecting Pathogens.Biosensors · 2022Review
- Label-Free Electrochemical Aptasensor for the Detection of the 3-O-CBiosensors · 2022Article
- Quorum-sensing molecules: Sampling, identification and characterization ofSaudi journal of biological sciences · 2022Article
- Using the microbiome in clinical practice.Microbial biotechnology · 2022Article
- Risk Factors for Carbapenem Resistant Gram Negative Bacteria (CR-GNB) Carriage Upon Admission to the Gastroenterology Department in a Tertiary First Class Hospital of China: Development and Assessment of a New Predictive Nomogram.Infection and drug resistance · 2022Article
- Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting.Frontiers in microbiology · 2022Review
- Bacterial Lighthouses-Real-Time Detection ofBiosensors · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the discovery and subsequent use of penicillin, antibiotics have been used to treat most bacterial infections in the U.S. Over time, the repeated prescription of many antibiotics has given rise to many antibiotic-resistant microbes. A bacterial strain becomes resistant by horizontal gene transfer, where surviving microbes acquire genetic material or DNA fragments from adjacent bacteria that encode for resistance. In order to avoid significant bacterial resistance, novel and target therapeutics are needed. Further advancement of diagnostic technologies could be used to develop novel treatment strategies. The use of biosensors to detect quorum-sensing signaling molecules has the potential to provide timely diagnostic information toward mitigating the multidrug-resistant bacteria epidemic. Resistance and pathogenesis are controlled by quorum-sensing (QS) circuits. QS systems secrete or passively release signaling molecules when the bacterial concentration reaches a certain threshold. Signaling molecules give an early indication of virulence. Detection of these compounds in vitro or in vivo can be used to identify the onset of infection. Whole-cell and cell-free biosensors have been developed to detect quorum-sensing signaling molecules. This review will give an overview of quorum networks in the most common pathogens found in chronic and acute infections. Additionally, the current state of research surrounding the detection of quorum-sensing molecules will be reviewed. Followed by a discussion of future works toward the advancement of technologies to quantify quorum signaling molecules in chronic and acute infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.