Evidence map›Paper›PMID 32429303›Full record

ArticleDiagnostics (Basel, Switzerland)2020

Functional Magnetic Resonance Imaging in the Final Stage of Creutzfeldt-Jakob Disease.

Stefan M Golaszewski, Bettina Wutzl, Axel F Unterrainer, Cristina Florea, Kerstin Schwenker, Vanessa N Frey, Martin Kronbichler, Frank Rattay, Raffaele Nardone, Larissa Hauer and 2 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Stefan M GolaszewskiDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Bettina WutzlDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Axel F UnterrainerInstitute of Neuroanesthesiology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Cristina FloreaDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Kerstin SchwenkerDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Vanessa N FreyDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Martin KronbichlerNeuroscience Institute, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Frank RattayInstitute for Analysis and Scientific Computing, Technical University of Vienna, 1040 Vienna, Austria.ORCID 0000-0002-2819-8827
Raffaele NardoneDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Larissa HauerDepartment of Psychiatry, Psychotherapy and Psychosomatic Medicine, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Johann SellnerDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0000-0001-8749-5533
Eugen TrinkaDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Paracelsus Medical University · ATUniversity of Vienna · ATUniversity of Salzburg · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare fatal degenerative disease of the central nervous system. The clinical course is characterized by rapid progression of neurological and neuromuscular symptoms. The late stage with loss of consciousness is not well characterized. We report a 62-year-old male patient with sCJD with the clinical picture of a vegetative state/apallic syndrome, in whom we studied cortical responses using a vibration paradigm. The functional magnetic resonance imaging (fMRI) investigation demonstrated a clear response within the sensorimotor cortex, the cerebellum, the parietal cortex, the insular, and frontal inferior region. The finding of persistent cortical activity on fMRI in a patient with CJD in a state of unconsciousness has implications for the clinical management and for ethical considerations.

Indexed as

alinetic mutismapallic syndromecomaCreutzfeldt-Jakob diseasefunctional magnetic resonance imagingsensorimotor cortexvibration paradigm

Identifiers

PMID32429303
PMCPMC7277986
OpenAlexW3024770536

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.