Evidence map›Paper›PMID 32429219›Full record

ArticleBrain sciences2020

Deep Brain Stimulation for Gilles de la Tourette Syndrome: Toward Limbic Targets.

Domenico Servello, Tommaso Francesco Galbiati, Roberta Balestrino, Guglielmo Iess, Edvin Zekaj, Sara De Michele, Mauro Porta

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Domenico ServelloNeurosurgical Department, IRCCS Istituto Ortopedico Galeazzi, Milan, 20100, Lombardia, Italy.
Tommaso Francesco GalbiatiNeurosurgical Department, IRCCS Istituto Ortopedico Galeazzi, Milan, 20100, Lombardia, Italy.
Roberta BalestrinoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, 10100 Torino, Italy.
Guglielmo IessNeurosurgical Department, IRCCS Istituto Ortopedico Galeazzi, Milan, 20100, Lombardia, Italy.
Edvin ZekajNeurosurgical Department, IRCCS Istituto Ortopedico Galeazzi, Milan, 20100, Lombardia, Italy.
Sara De MicheleTourette's Syndrome and Movement Disorders Center, IRCCS Istituto Ortopedico Galeazzi, 20100 Milan, Lombardia, Italy.
Mauro PortaTourette's Syndrome and Movement Disorders Center, IRCCS Istituto Ortopedico Galeazzi, 20100 Milan, Lombardia, Italy.
Istituto Ortopedico Galeazzi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gilles de la Tourette syndrome (GTS) is a complex neurodevelopmental disorder characterized by tics and, frequently, psychiatric and behavioral comorbidities. Above all, obsessive compulsive disorder/behavior (OCD/OCB) influences the clinical picture and has a severe impact on quality of life, eventually more than the tics themselves. Deep brain stimulation (DBS) is an effective therapy in selected, refractory cases. Clinical response to DBS may vary according to the clinical picture, comorbidities, and to the anatomical target. This retrospective study compares the results obtained from DBS in the ventralis oralis/centromedian-parascicular nucleus of the thalamus (Voi-Cm/Pf) (41 patients) and antero-medial Globus Pallidus internus (am-GPi) (14 patients), evaluating clinical response over time by means of Yale Global Tic Severity Scale (YGTSS) and Yale-Brown Obsessive-Compulsive Scale (YBOCS) scores over a period of 48 months. A significant and stable improvement in the YGTSS and YBOCS has been obtained in both groups (

Indexed as

antero-medial Globus Pallidus internusDeep Brain Stimulationobsessive compulsive disorderTourette Syndromeventralis oralis/centromedian-parascicular nucleus of the thalamus

Identifiers

PMID32429219
PMCPMC7287742
OpenAlexW3024742234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.