ReviewNutrients2020
Vitamin D Effects on the Immune System from Periconception through Pregnancy.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Vitamin D and biomarkers of inflammation and oxidative stress among pregnant women: a systematic review of observational studies.BMC immunology · 2023Pooled it
- The Role of Macrophages in Endometrial Cyclical Changes and Female Reproductive System Diseases: A Review.Current issues in molecular biology · 2026Review
- Review
- Review
- Retinoic Acid and Calcitriol Protect Mouse Primordial Follicles from Cyclophosphamide Treatment-Induced Apoptosis.Antioxidants (Basel, Switzerland) · 2026Article
- Vitamin D levels and prolonged menstrual cycle in women with polycystic ovary syndrome: a cross-sectional study.Frontiers in nutrition · 2026Article
- Article
- The Role of Vitamin D Supplementation in Preventing Pre-Eclampsia: A Review of Randomized Controlled Trials with Meta-Analysis.Healthcare (Basel, Switzerland) · 2025Review
- The role of vitamin D deficiency in placental dysfunction: A systematic review.Metabolism open · 2025Article
- Constructing a logistic regression-based prediction model for subsequent early pregnancy loss in women with pregnancy loss.European journal of medical research · 2025Article
- Vitamin D affects antiphospholipid syndrome by regulating T cells (Review).International journal of molecular medicine · 2025Review
- Evaluation of placental growth factor, Vitamin D, and systemic inflammatory index as predictive biomarkers for preeclampsia severity: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Article
- Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review.Frontiers in nutrition · 2025Review
- Article
- Longitudinal changes in vitamin D during twin pregnancy: association with maternal-neonatal outcomes.Frontiers in nutrition · 2025Article
- Advancement in predictive biomarkers for gestational diabetes mellitus diagnosis and related outcomes: a scoping review.BMJ open · 2024Article
- Review
- The role of vitamin D3 in follicle development.Journal of ovarian research · 2024Review
- Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D is a well-known secosteroid and guardian of bone health and calcium homeostasis. Studies on its role in immunomodulatory functions have expanded its field in recent years. In addition to its impact on human physiology, vitamin D influences the differentiation and proliferation of immune system modulators, interleukin expression and antimicrobial responses. Furthermore, it has been shown that vitamin D is synthesized in female reproductive tissues and, by modulating the immune system, affects the periconception period and reproductive outcomes. B cells, T cells, macrophages and dendritic cells can all synthesize active vitamin D and are involved in processes which occur from fertilization, implantation and maintenance of pregnancy. Components of vitamin D synthesis are expressed in the ovary, decidua, endometrium and placenta. An inadequate vitamin D level has been associated with recurrent implantation failure and pregnancy loss and is associated with pregnancy-related disorders like preeclampsia. This paper reviews the most important data on immunomodulatory vitamin D effects in relation to the immune system from periconception to pregnancy and provides an insight into the possible consequences of vitamin D deficiency before and during pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.