Evidence map›Paper›PMID 32429154›Full record

ArticleInternational journal of molecular sciences2020

Novel 3'-Substituted-1',2',4'-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their

Andrey V Markov, Aleksandra V Sen'kova, Irina I Popadyuk, Oksana V Salomatina, Evgeniya B Logashenko, Nina I Komarova, Anna A Ilyina, Nariman F Salakhutdinov, Marina A Zenkova

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. SoloxoloneInternational journal of molecular sciences · 2025
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  3. Biochemistry and biophysics reports · 2025
    Article
  4. Review
  5. A Novel 3-ACS omega · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Andrey V MarkovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.ORCID 0000-0001-7569-9555
Aleksandra V Sen'kovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
Irina I PopadyukN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 9, 630090 Novosibirsk, Russia.
Oksana V SalomatinaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
Evgeniya B LogashenkoInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
Nina I KomarovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 9, 630090 Novosibirsk, Russia.
Anna A IlyinaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
Nariman F SalakhutdinovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 9, 630090 Novosibirsk, Russia.
Marina A ZenkovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
Institute of Chemical Biology and Fundamental Medicine · RUNovosibirsk Institute of Organic Chemistry · RU

Funding

Russian Foundation for Basic Research 16-33-00414Russian Science Foundation 17-75-20120Russian State funded budget project of ICBFM SB RAS AAAA-A17-117020210024-8
6 · The paper itself

Abstract

A series of novel 18βH-glycyrrhetinic acid (GA) derivatives containing 3'-(alkyl/phenyl/pyridin(-2″, -3″, and -4″)-yl)-1',2',4'-oxadiazole moieties at the C-30 position were synthesized by condensation of triterpenoid's carboxyl group with corresponding amidoximes and further cyclization. Screening of the cytotoxicity of novel GA derivatives on a panel of tumor cell lines showed that the 3-acetoxy triterpenoid intermediates-

Indexed as

AcylationAnti-Inflammatory AgentsAntineoplastic AgentsApoptosisCarrageenanCaspasesCell DeathCell ProliferationGlycyrrhetinic AcidHeLa CellsHumansInflammationMelanoma, ExperimentalMitochondriaNeoplasm MetastasisOxadiazolesamidoximeAnti-Inflammatory AgentsAntineoplastic AgentsCarrageenanCaspasesGlycyrrhetinic AcidOxadiazolesOximes18βH-glycyrrhetinic acidanti-inflammatory activityantitumor activityapoptosisderivativesheterocyclic moietymetastasismolecular dockingoxadiazoletarget prediction

Identifiers

PMID32429154
PMCPMC7279002
OpenAlexW3024821363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.