Evidence map›Paper›PMID 32429143›Full record

ArticleAntibiotics (Basel, Switzerland)2020

One-Step Differential Detection of OXA-48-Like Variants Using High-Resolution Melting (HRM) Analysis.

Min Yi Lau, Kartini Abdul Jabar, Kek Heng Chua, Boon Pin Kee, Sasheela Sri La Sri Ponnampalavanar, Chun Wie Chong, Cindy Shuan Ju Teh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Min Yi LauDepartment of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Kartini Abdul JabarDepartment of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Kek Heng ChuaDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Boon Pin KeeDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Sasheela Sri La Sri PonnampalavanarDepartment of Infectious Diseases, University Malaya Medical Centre, Kuala Lumpur 50603, Malaysia.
Chun Wie ChongSchool of Pharmacy, Monash University Malaysia, Subang Jaya 47500, Malaysia.
Cindy Shuan Ju TehDepartment of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

Funding

International Society for Infectious Diseases IF2016-2015.Malaysia Toray Science Foundation PV051-2018
6 · The paper itself

Abstract

OXA-48-like carbapenemase gene remains a hidden threat, as different OXA-48 variants have varying presentations of susceptibility to antibiotics that might affect the treatment decisions. Rapid detection and differentiation of OXA-48-like carbapenemase genes are critical for targeted treatment and infection control. In this study, we aimed to develop high-resolution melting (HRM) analysis for the differentiation of OXA-48 variants. HRM analysis is a post-polymerase chain reaction (post-PCR) method for identification of small variations in nucleic acid sequences based on the PCR dissociation curve. A total of 82 bacterial strains, which consisted of

Indexed as

carbapenem-resistant Klebsiella pneumoniaeEnterobacteriaceaeHRMOXA-48real-time PCR

Identifiers

PMID32429143
PMCPMC7277688

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