Evidence map›Paper›PMID 32429114›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Influence of the Introduced Chitin Nanofibrils on Biomedical Properties of Chitosan-Based Materials.

Ekaterina N Maevskaia, Anton S Shabunin, Elena N Dresvyanina, Irina P Dobrovol'skaya, Vladimir E Yudin, Moisey B Paneyah, Andrey M Fediuk, Petr L Sushchinskii, Gerald P Smirnov, Evgeniy V Zinoviev and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Ekaterina N MaevskaiaDepartment of Medical Physics, Peter the Great St. Petersburg Polytechnic University,Polytechnicheskaya Street 29, 195251 Saint Petersburg, Russia.
Anton S ShabuninDepartment of Medical Physics, Peter the Great St. Petersburg Polytechnic University,Polytechnicheskaya Street 29, 195251 Saint Petersburg, Russia.
Elena N DresvyaninaDepartment of Medical Physics, Peter the Great St. Petersburg Polytechnic University,Polytechnicheskaya Street 29, 195251 Saint Petersburg, Russia.
Irina P Dobrovol'skayaDepartment of Medical Physics, Peter the Great St. Petersburg Polytechnic University,Polytechnicheskaya Street 29, 195251 Saint Petersburg, Russia.
Vladimir E YudinDepartment of Medical Physics, Peter the Great St. Petersburg Polytechnic University,Polytechnicheskaya Street 29, 195251 Saint Petersburg, Russia.
Moisey B PaneyahLaboratory of Experimental Surgery of Scientific Research Center, Saint Petersburg State Pediatrical Medical University, Litovskaya Street 2, 194100 Saint Petersburg, Russia.
Andrey M FediukLaboratory of Experimental Surgery of Scientific Research Center, Saint Petersburg State Pediatrical Medical University, Litovskaya Street 2, 194100 Saint Petersburg, Russia.
Petr L SushchinskiiLaboratory of Experimental Surgery of Scientific Research Center, Saint Petersburg State Pediatrical Medical University, Litovskaya Street 2, 194100 Saint Petersburg, Russia.
Gerald P SmirnovInstitute of Textile and Fashion, Saint Petersburg State University of Industrial Technologies and Design, Bolshaya Morskaya Street 18, 191186 Saint Petersburg, Russia.
Evgeniy V ZinovievLaboratory of Experimental Surgery of Scientific Research Center, Saint Petersburg State Pediatrical Medical University, Litovskaya Street 2, 194100 Saint Petersburg, Russia.
Pierfrancesco MorgantiDepartment of Experimental Medicine, University of Campania Luigi Vanvitelli, via L. De Crecchio 7, 80138 Naples, Italy.
Peter the Great St. Petersburg Polytechnic University · RUSaint Petersburg State Pediatric Medical University · RUSaint-Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine · RUSaint-Petersburg State University of Technology and Design · RUUniversity of Campania "Luigi Vanvitelli" · IT

Funding

Russian Science Foundation 19-73-30003
6 · The paper itself

Abstract

Hemorrhage occurring during and after surgery still remains one of the biggest problems in medicine. Although a large number of hemostatic products have been created, there is no universal preparation; thus, the development of new materials is an urgent task. The aim of this research is to increase hemostatic properties of chitosan by introducing chitin nanofibrils (ChNF). The blood absorbance by ChNF-containing chitosan sponges and time-until-arrest of bleeding were studied. Non-woven materials containing 0.5% of ChNF and materials without chitin were obtained. The studies of ζ-potential showed that the material containing 0.5% ChNF had relatively a high positive charge, but efficiencies of both materials for hemorrhage arrest were comparable to those of commercial hemostatic products (Surgicel and TachoComb). To investigate the interaction between the materials and living organism, histological studies and optical microscopy studies were conducted after implantation of fibers. Despite bioinertness of fibers, implantation of non-woven materials led to formation of significant granulomas.

Indexed as

chitin nanofibrilschitosanhemorrhagehemostatic material

Identifiers

PMID32429114
PMCPMC7279343
OpenAlexW3024690673

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.