Evidence map›Paper›PMID 32429033›Full record

ArticleMolecules (Basel, Switzerland)2020

Kimberly Fung, Delphine Vivier, Outi Keinänen, Elaheh Khozeimeh Sarbisheh, Eric W Price, Brian M Zeglis

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Mucin-Targeted Antibodies for Ovarian Cancer.Seminars in nuclear medicine · 2025
    Review
  2. Review
  3. In Vivo Detection ofInternational journal of biomedical imaging · 2024
    Article
  4. Article
  5. CD133 as a Biomarker for an Autoantibody-to-ImmunoPET Paradigm for the Early Detection of Small Cell Lung Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  6. Review
  7. Pancreatic Ductal Adenocarcinoma: The Dawn of the Era of Nuclear Medicine?International journal of molecular sciences · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Kimberly FungDepartment of Chemistry, Hunter College, City University of New York, New York, NY 10021, USA.
Delphine VivierDepartment of Chemistry, Hunter College, City University of New York, New York, NY 10021, USA.
Outi KeinänenDepartment of Chemistry, Hunter College, City University of New York, New York, NY 10021, USA.ORCID 0000-0002-3939-6706
Elaheh Khozeimeh SarbishehDepartment of Chemistry, University of Saskatchewan, Saskatoon, SK S7N 5B5, Canada.
Eric W PriceDepartment of Chemistry, University of Saskatchewan, Saskatoon, SK S7N 5B5, Canada.ORCID 0000-0002-8619-1199
Brian M ZeglisDepartment of Chemistry, Hunter College, City University of New York, New York, NY 10021, USA.
The Graduate Center, CUNY · USUniversity of Saskatchewan · CACity University of New York · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Pretargeted Clinical Imaging of CA19.9 in Pancreatic CancerU01CA221046 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ZEGLIS, BRIAN MATTHEW · 2018 to 2022
$3.5M
The Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4M
Novel Reagents for Rapid and Stable Thiol-Based BioconjugationsR01CA240963 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2019 to 2023
$1.6M
A PET Radiotracer for Diagnostic and Theranostics Imaging in Lyme DiseaseR21EB030275 · NIBIB · HUNTER COLLEGE · PI QIU, WEIGANG, ZEGLIS, BRIAN MATTHEW · 2020 to 2021
$429k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204167NCI NIH HHS R01 CA240963NCI NIH HHS U01 CA221046NIH HHS R01CA204167NIH HHS R01CA240963NIH HHS U01CA221046
6 · The paper itself

Abstract

High expression levels of the tumor-associated antigen MUC1 have been correlated with tumor aggressiveness, poor response to therapy, and poor survival in several tumor types, including breast, pancreatic, and epithelial ovarian cancer. Herein, we report the synthesis, characterization, and in vivo evaluation of a novel radioimmunoconjugate for the immuno-positron emission tomography (immunoPET) imaging of MUC1 expression based on the AR20.5 antibody. To this end, we modified AR20.5 with the chelator desferrioxamine (DFO) and labeled it with the positron-emitting radiometal zirconium-89 (t

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, NeoplasmBiological AvailabilityDeferoxamineFemaleGene ExpressionHeterograftsHumansImmunoconjugatesLymphatic MetastasisMiceMice, NudeMucin-1NeoplasmsPositron-Emission TomographyAntibodies, MonoclonalAntibodies, NeoplasmDeferoxamineImmunoconjugatesMUC1 protein, humanMucin-1RadioisotopesZirconiumZirconium-89AR20.5MUC1mucin 1PETpositron emission tomographyzirconium-89

Identifiers

PMID32429033
PMCPMC7287814
OpenAlexW3025026498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.