ArticleAddiction biology2021
Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls.
Article in Addiction biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Cognitive Functioning and Its Stability Among Young Adults with Perinatal HIV Exposure or Acquisition in a U.S.-Based Longitudinal Cohort Study.AIDS and behavior · 2026Article
- Adolescent onset of volitional ethanol intake normalizes sex differences observed with adult-onset ethanol intake and negative affective behaviors during protracted forced abstinence.Psychopharmacology · 2026Article
- The individuality of single-frame functional brain connectivity.bioRxiv : the preprint server for biology · 2026Article
- Socioemotional and Executive Control Mismatch in Adolescence and Risks for Initiating Drinking.JAMA network open · 2025Article
- Adverse childhood experiences and post-traumatic stress impacts on brain connectivity and alcohol use in adolescence.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025Article
- Triple network dynamics and future alcohol consumption in adolescents.Alcohol, clinical & experimental research · 2025Article
- SpaRG: Sparsely Reconstructed Graphs for Generalizable fMRI Analysis.Machine learning in clinical neuroimaging : 7th international workshop, MLCN 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, proceedings. MLCN (Workshop) (7th : 2024 : Marrakesh, Morocco) · 2025Article
- Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood.Developmental cognitive neuroscience · 2024Article
- Contrasting topologies of synchronous and asynchronous functional brain networks.Network neuroscience (Cambridge, Mass.) · 2024Article
- Differences in Brain Network Topology Based on Alcohol Use History in Adolescents.Brain sciences · 2023Article
- Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- The Influence of Sex on Hippocampal Neurogenesis and Neurotrophic Responses on the Persistent Effects of Adolescent Intermittent Ethanol Exposure into Adulthood.Neuroscience · 2022Article
- Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain.Nature communications · 2022Article
- Sex-specific effects of adolescent intermittent ethanol exposure-induced dysregulation of hippocampal glial cells in adulthood.Alcohol (Fayetteville, N.Y.) · 2022Article
- Alcohol and the Adolescent Brain: What We've Learned and Where the Data Are Taking Us.Alcohol research : current reviews · 2022Review
- Alcohol and Cannabis Use and the Developing Brain.Alcohol research : current reviews · 2021Review
- The individuality of single-frame functional brain connectivity.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
22 authors at 9 institutions in 1 country.
Funding
Abstract
Exogenous causes, such as alcohol use, and endogenous factors, such as temperament and sex, can modulate developmental trajectories of adolescent neurofunctional maturation. We examined how these factors affect sexual dimorphism in brain functional networks in youth drinking below diagnostic threshold for alcohol use disorder (AUD). Based on the 3-year, annually acquired, longitudinal resting-state functional magnetic resonance imaging (MRI) data of 526 adolescents (12-21 years at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) cohort, developmental trajectories of 23 intrinsic functional networks (IFNs) were analyzed for (1) sexual dimorphism in 259 participants who were no-to-low drinkers throughout this period; (2) sex-alcohol interactions in two age- and sex-matched NCANDA subgroups (N = 76 each), half no-to-low, and half moderate-to-heavy drinkers; and (3) moderating effects of gender-specific alcohol dose effects and a multifactorial impulsivity measure on IFN connectivity in all NCANDA participants. Results showed that sex differences in no-to-low drinkers diminished with age in the inferior-occipital network, yet girls had weaker within-network connectivity than boys in six other networks. Effects of adolescent alcohol use were more pronounced in girls than boys in three IFNs. In particular, girls showed greater within-network connectivity in two motor networks with more alcohol consumption, and these effects were mediated by sensation-seeking only in girls. Our results implied that drinking might attenuate the naturally diminishing sexual differences by disrupting the maturation of network efficiency more severely in girls. The sex-alcohol-dose effect might explain why women are at higher risk of alcohol-related health and psychosocial consequences than men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.