ArticleAmerican heart journal2020
Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study.
Article in American heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Somatic growth in single ventricle patients: A systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2023Pooled it
- Frequency and Progression of Lung Disease Patterns in Patients with Fontan and Tetralogy of Fallot.Pediatric cardiology · 2026Article
- Factors Influencing Weight Gain at Different Stages of the Fontan Pathway for Children with Functionally Single Ventricle Heart Disease.Pediatric cardiology · 2026Article
- Body Mass Index and Physical Activity Among U.S. Children with Congenital Heart Conditions.Pediatric cardiology · 2026Article
- Growth Failure in Children with Congenital Heart Disease.Children (Basel, Switzerland) · 2025Review
- Quality of Life in the Danish Fontan Population is Unchanged Over the Past Decade-A Nationwide Longitudinal Study.Pediatric cardiology · 2025Article
- Relationship Between Obesity and Global Longitudinal Strain in the Pediatric Single Ventricle Fontan Population Across Ventricular Morphologies.Journal of the American Heart Association · 2024Article
- Association of Body Mass Index With Clinical Features and Outcomes in Adults With Fontan Palliation.Journal of the American Heart Association · 2023Article
- Body Mass Index Trajectory and Outcome Post Fontan Procedure.Journal of the American Heart Association · 2022Article
- Exercise capacity after total cavopulmonary anastomosis: a longitudinal paediatric and adult study.ESC heart failure · 2022Article
- New insights on growth trajectory in infants with complex congenital heart disease.Journal of pediatric nursingArticle
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundGrowth abnormalities in single-ventricle survivors may reduce quality of life (QoL) and exercise capacity.
methodsThis multicenter, longitudinal analysis evaluated changes in height and body mass index (BMI) compared to population norms and their relationship to mortality, ventricular morphology, QoL, and exercise capacity in the Pediatric Heart Network Fontan studies.
resultsFontan 1 (F1) included 546 participants (12 ± 3.4 years); Fontan 2 (F2), 427 (19 ± 3.4 years); and Fontan 3 (F3), 362 (21 ± 3.5 years), with ~60% male at each time point. Height z-score was -0.67 ± -1.27, -0.60 ± 1.34, and- 0.43 ± 1.14 at F1-F3, lower compared to norms at all time points (P ≤ .001). BMI z-score was similar to population norms. Compared to survivors, participants who died had lower height z-score (P ≤ .001). Participants with dominant right ventricle (n = 112) had lower height z-score (P ≤ .004) compared to dominant left (n = 186) or mixed (n = 64) ventricular morphologies. Higher height z-score was associated with higher Pediatric Quality of Life Inventory for the total score (slope = 2.82 ± 0.52; P ≤ .001). Increase in height z-score (F1 to F3) was associated with increased oxygen consumption (slope = 2.61 ± 1.08; P = .02), whereas, for participants >20 years old, an increase in BMI (F1 to F3) was associated with a decrease in oxygen consumption (slope = -1.25 ± 0.33; P ≤ .001).
conclusionsFontan survivors, especially those with right ventricular morphology, are shorter when compared to the normal population but have similar BMI. Shorter stature was associated with worse survival. An increase in height z-score over the course of the study was associated with better QoL and exercise capacity; an increase in BMI was associated with worse exercise capacity.
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Registered trials
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