Evidence map›Paper›PMID 32428585›Full record

ReviewNeurobiology of learning and memory2020

The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents.

Laurel R Seemiller, Thomas J Gould

Open access · greenAbstract readReview
In one paragraph

Review in Neurobiology of learning and memory, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  7. Consequences of adolescent drug use.Translational psychiatry · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laurel R SeemillerDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.
Thomas J GouldDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA. Electronic address: tug70@psu.edu.
Pennsylvania State University · US

Funding

Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
Interstrain variability in long-term cognitive effects of adolescent nicotine exposureR03DA048166 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI GOULD, THOMAS J · 2019 to 2020
$160k
NIDA NIH HHS R03 DA048166NIGMS NIH HHS T32 GM108563
6 · The paper itself

Abstract

Adolescent alcohol use is a widespread problem in the United States. In both humans and rodents, alcohol can impair learning and memory processes mediated by forebrain areas such as the prefrontal cortex (PFC) and hippocampus (HC). Adolescence is a period in which alcohol use often begins, and it is also a time that can be uniquely sensitive to the detrimental effects of alcohol. Exposure to alcohol during adolescence can cause persisting alterations in PFC and HC neurobiology that are linked to cognitive impairments, including changes in neurogenesis, inflammation, and various neurotransmitter systems in rodent models. Consistent with this, chronic adolescent alcohol exposure can cause PFC-dependent learning impairments that persist into adulthood. Deficits in adult HC-dependent learning after adolescent alcohol exposure have also been reported, but these findings are less consistent. Overall, evidence summarized in this review indicates that adolescent exposure to alcohol can produce long-term detrimental effects on forebrain-dependent cognitive processes.

Indexed as

LearningAlcoholismAnimalsCognitive DysfunctionEthanolHippocampusHumansMicePrefrontal CortexRatsUnderage DrinkingEthanolAdolescenceAlcoholHippocampusLearningMemoryPrefrontal cortex

Identifiers

PMID32428585
PMCPMC7797082
OpenAlexW3025530761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.