Evidence map›Paper›PMID 32428513›Full record

ArticleChest2020

Baseline Characteristics and Progression of a Spectrum of Interstitial Lung Abnormalities and Disease in Rheumatoid Arthritis.

Leticia Kawano-Dourado, Tracy J Doyle, Karina Bonfiglioli, Márcio V Y Sawamura, Renato H Nakagawa, Fábio E Arimura, Hye J Lee, Diana Arrais de Souza Rangel, Cleonice Bueno, Carlos R R Carvalho and 4 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06235645 (dEtection of rheumAtoid aRthritis - Interstitial Lung dIseasE by Thoracic ultRasound), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06235645 recruitingnot on this mapstarted 2024, after this paper: background citation

dEtection of rheumAtoid aRthritis - Interstitial Lung dIseasE by Thoracic ultRasound

TypeobservationalSponsorUniversity Hospital, ToursRan2024 to 2027Enrolled280ConditionsRheumatoid Arthritis, Interstitial Lung Disease, Thoracic Ultrasound, Lung UltrasoundArmsLung ultrasound (LUS)
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Lung disease in rheumatoid arthritis.Nature reviews. Rheumatology · 2026
    Review
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Observational
  13. Treating connective tissue disease-associated interstitial lung disease - think outside the box: a perspective.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  14. Observational
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Leticia Kawano-DouradoPulmonary Division, Hospital das Clinicas HCFMUSP, Medical School, University of Sao Paulo, São Paulo, Brazil; Research Institute, Hospital do Coração (HCor), São Paulo, Brazil. Electronic address: ldourado@hcor.com.br.
Tracy J DoylePulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Karina BonfiglioliHeart Institute (InCor), the Division of Rheumatology, Hospital das Clinicas HCFMUSP, Medical School, University of Sao Paulo, São Paulo, Brazil.
Márcio V Y SawamuraDivision of Radiology, Hospital das Clinicas HCFMUSP, Medical School, University of Sao Paulo, São Paulo, Brazil.
Renato H NakagawaResearch Institute, Hospital do Coração (HCor), São Paulo, Brazil.
Fábio E ArimuraPulmonary Division, Hospital das Clinicas HCFMUSP, Medical School, University of Sao Paulo, São Paulo, Brazil.
Hye J LeeDivision of Radiology, Hospital das Clinicas HCFMUSP, Medical School, University of Sao Paulo, São Paulo, Brazil.
Diana Arrais de Souza RangelPulmonary Division, Hospital das Clinicas HCFMUSP, Medical School, University of Sao Paulo, São Paulo, Brazil.
Cleonice BuenoDivision of Radiology, Hospital das Clinicas HCFMUSP, Medical School, University of Sao Paulo, São Paulo, Brazil.
Carlos R R CarvalhoPulmonary Division, Hospital das Clinicas HCFMUSP, Medical School, University of Sao Paulo, São Paulo, Brazil.
Maria Laura SabbagCentro Universitário São Camilo-São Paulo, São Paulo, Brazil.
Camila MolinaCentro Universitário São Camilo-São Paulo, São Paulo, Brazil.
Ivan O RosasPulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Ronaldo A KairallaPulmonary Division, Hospital das Clinicas HCFMUSP, Medical School, University of Sao Paulo, São Paulo, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRCentro Universitário São Camilo · BRHospital do Coração · BRBrigham and Women's Hospital · USHarvard University · US

Funding

Clinical and Molecular Characteristics of Rheumatoid Arthritis-associated ILDK23HL119558 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DOYLE, TRACY JENNIFER · 2015 to 2018
$763k
Molecular and Genetic Characteristics of Progressive Rheumatoid Arthritis-associated Interstitial Lung DiseaseR03HL148484 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DOYLE, TRACY JENNIFER · 2019 to 2020
$134k
NHLBI NIH HHS K23 HL119558NHLBI NIH HHS R03 HL148484
6 · The paper itself

Abstract

backgroundInterstitial lung abnormalities (ILA) and interstitial lung disease (ILD) are seen in up to 60% of individuals with rheumatoid arthritis (RA), some of which will progress to have a significant impact on morbidity and mortality rates. Better characterization of progressive interstitial changes and identification of risk factors that are associated with progression may enable earlier intervention and improved outcomes. RESEARCH QUESTION: What are baseline characteristics associated with RA-ILD progression? STUDY DESIGN AND

methodsWe performed a retrospective study in which all clinically indicated CT chest scans in adult individuals with RA from 2014 to 2016 were evaluated for interstitial changes, and the data were further subdivided into ILA and ILD based on clinical record review. Progression was determined visually and subsequently semiquantified.

resultsThose individuals with a spectrum of interstitial changes (64 of 293) were older male smokers and less likely to be receiving biologics/small molecule disease-modifying antirheumatic drugs. Of 44% of the individuals with ILA, 46% had had chest CT scans performed for nonpulmonary indications. Of the 56 individuals with ILA/ILD with sequential CT scans, 38% had evidence of radiologic progression over 4.4 years; 29% of of individuals with ILA progressed. Risk factors for progressive ILA/ILD included a subpleural distribution and higher baseline involvement.

interpretationOf 293 individuals with RA with clinically indicated CT scans, interstitial changes were observed in 22%, one-half of whom had had a respiratory complaint at the time of imaging; radiologic progression was seen in 38%. Of individuals with progressive ILA, one-half had had baseline CT scans performed for nonpulmonary indications. Subpleural distribution and higher baseline ILA/ILD extent were risk factors associated with progression. Prospective longitudinal studies of RA-ILA are necessary.

Indexed as

Tomography, X-Ray ComputedAgedArthritis, RheumatoidDisease ProgressionFemaleHumansLung Diseases, InterstitialMaleMiddle AgedRetrospective StudiesRisk Factorsinterstitial lung diseasepulmonary fibrosisradiologyrheumatoid arthritisthoracic

Identifiers

PMID32428513
PMCPMC7545491
OpenAlexW3024422520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.