ArticleNeuron2020
Experience-Dependent Reorganization Drives Development of a Binocularly Unified Cortical Representation of Orientation.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Eye-specific drive and binocular suppression in mouse visual cortex during critical period development.bioRxiv : the preprint server for biology · 2026Article
- Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Article
- Premature vision drives aberrant development of response properties in primary visual cortex.eLife · 2025Article
- A Critical Look at Critical Periods.Annual review of vision science · 2025Review
- Retinal waves reveal axial biases in modular patterns of cortical activity that predict future orientation preferences.bioRxiv : the preprint server for biology · 2025Article
- Premature vision drives aberrant development of response properties in primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- The world through infant eyes: Evidence for the early emergence of the cardinal orientation bias.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The developmental emergence of reliable cortical representations.Nature neuroscience · 2025Article
- A unifying framework for functional organization in early and higher ventral visual cortex.Neuron · 2024Article
- Binocular receptive-field construction in the primary visual cortex.Current biology : CB · 2024Article
- Development of ocular dominance columns across rodents and other species: revisiting the concept of critical period plasticity.Frontiers in neural circuits · 2024Review
- The Cousa objective: a long-working distance air objective for multiphoton imaging in vivo.Nature methods · 2024Article
- Widespread and Multifaceted Binocular Integration in the Mouse Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Experience dependent plasticity of higher visual cortical areas in the mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A Unifying Principle for the Functional Organization of Visual Cortex.bioRxiv : the preprint server for biology · 2023Article
- Neural circuits for binocular vision: Ocular dominance, interocular matching, and disparity selectivity.Frontiers in neural circuits · 2023Review
- Article
- Article
- A model for the development of binocular congruence in primary visual cortex.Scientific reports · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Across sensory areas, neural microcircuits consolidate streams of information into unified representations of the external world. In the carnivore visual cortex, where eye-specific inputs first converge, it has been posited that a single, binocularly aligned modular orientation representation develops independent of sensory experience. In this study of ferret visual cortex using in vivo calcium imaging, we find evidence for a different developmental process. Early in development, contralateral, ipsilateral, or binocular stimulation each yield well-organized modular representations of orientation that display features of mature cortex. However, comparison of these representations reveals considerable misalignment that is evident at both modular and cellular scales. Experience-dependent processes drive reorganization of these three representations toward a single binocularly aligned representation resembling the early binocular representation through shifts in cellular orientation preference. Thus, while orderly modular networks of orientation preference initially arise independent of visual experience, experience is critical for the alignment of these early representations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.