Evidence map›Paper›PMID 32428267›Full record

ArticleBiomedical chromatography : BMC2020

Metabolomic characterization of semen from asthenozoospermic patients using ultra-high-performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry.

Li Li, Xinrui Hao, Hua Chen, Liyuan Wang, Aolei Chen, Xiaotian Song, Zhiyan Hu, Ying Su, Han Lin, Pei Fan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical chromatography : BMC, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  11. Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats.International journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Li LiZhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xinrui HaoZhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hua ChenReproductive Health Centre, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Liyuan WangReproductive Health Centre, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Aolei ChenReproductive Health Centre, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiaotian SongReproductive Health Centre, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhiyan HuZhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ying SuZhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Han LinZhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Pei FanZhejiang Provincial Key Laboratory of Orthopedics, Department of Orthopedics, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-6592-3071
Wenzhou Medical University · CN

Funding

National Natural Science Foundation of China 81702660Wenzhou Municipal Science and Technology Bureau funding Y20170149Wenzhou Municipal Science and Technology Bureau funding Y20180029Zhejiang Provincial Medical Health Science and Technology Plan Project 2017KY469Zhejiang Provincial Natural Science Foundation of China LQ17C120002Zhejiang Provincial Natural Science Foundation of China LQ18H040006
6 · The paper itself

Abstract

Asthenozoospermia (AS) is a common factor of male infertility, and its pathogenesis remains unclear. The purpose of this study was to investigate the differential seminal plasma metabolic pattern in asthenozoospermic men and to identify potential biomarkers in relation to spermatogenic dysfunction using sensitive ultra-high-performance liquid chromatography-tandem quadruple time-of-flight MS (UHPLC-Q-TOF/MS). The samples of seminal plasma from patients with AS (n = 20) and healthy controls (n = 20) were checked and differentiated by UHPLC-Q-TOF/MS. Compared with the control group, the AS group showed a total of nine significantly different metabolites, including increases in creatinine, uric acid, N

Indexed as

SemenAdenosineAdultAsthenozoospermiaChromatography, High Pressure LiquidHumansMaleMetabolomeMetabolomicsNiacinamideSemen AnalysisTandem Mass SpectrometryAdenosineNiacinamideN-methyladenosineasthenozoospermiaN6-methyladenosinenicotinamideUHPLC-Q-TOF/MS

Identifiers

PMID32428267
PMCPMC7507193
OpenAlexW3027283160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.