ArticleMemorias do Instituto Oswaldo Cruz2020
Genomic detection of a virus lineage replacement event of dengue virus serotype 2 in Brazil, 2019.
Article in Memorias do Instituto Oswaldo Cruz, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Dengue virus genetic diversity in unvaccinated and vaccinated dengue-infected individuals: an observational analysis of the Butantan-DV phase 3 trial in Brazil.Lancet regional health. Americas · 2026Article
- Dengue Incidence Following Mass Vaccination: An Interrupted Time Series Study in Paraná, Brazil.Tropical medicine and infectious disease · 2025Article
- SMART-RNA-Metavirome: a practical RNA metavirome platform compatible with high-throughput sequencing of both short and long reads.Infectious diseases of poverty · 2025Article
- Viral Metagenomic Next-Generation Sequencing for One Health Discovery and Surveillance of (Re)Emerging Viruses: A Deep Review.International journal of molecular sciences · 2025Review
- Dengue Virus Serotypes 1 and 2 Responsible for Dengue Burden in Amazonas: Epidemiological and Clinical Features.The American journal of tropical medicine and hygiene · 2025Article
- Genotypic diversity and molecular characterization of DENV-2 in a Peruvian endemic region from 2016 to 2022: displacement of American/Asian genotype.Frontiers in microbiology · 2025Article
- Climate, demography, immunology, and virology combine to drive two decades of dengue virus dynamics in Cambodia.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genomics for Arbovirus Surveillance: Considerations for Routine Use in Public Health Laboratories.Viruses · 2024Review
- Phylogenetics, Epidemiology and Temporal Patterns of Dengue Virus in Araraquara, São Paulo State.Viruses · 2024Article
- Detection of a Multiple Circulation Event of Dengue Virus 2 Strains in the Northern Region of Brazil.Tropical medicine and infectious disease · 2024Article
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- Technical comparison of MinIon and Illumina technologies for genotyping Chikungunya virus in clinical samples.Journal, genetic engineering & biotechnology · 2023Article
- Detection of DENV-2 and ZIKV coinfection in southeastern Brazil by serum and urine testing.Medical microbiology and immunology · 2023Article
- Phylogenetic Analysis of Transmission Dynamics of Dengue in Large and Small Population Centers, Northern Ecuador.Emerging infectious diseases · 2023Review
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- Review
- Multiple introductions and country-wide spread of DENV-2 genotype II (Cosmopolitan) in Brazil.Virus evolution · 2023Article
- Article
- Potential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings.Emerging microbes & infections · 2021Article
- Nanopore sequencing technology, bioinformatics and applications.Nature biotechnology · 2021Review
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
BACKGROUND Despite efforts to mitigate the impact of dengue virus (DENV) epidemics, the virus remains a public health problem in tropical and subtropical regions around the world. Most DENV cases in the Americas between January and July 2019 were reported in Brazil. São Paulo State in the southeast of Brazil has reported nearly half of all DENV infections in the country. OBJECTIVES To understand the origin and dynamics of the 2019 DENV outbreak. METHODS Here using portable nanopore sequencing we generated20 new DENV genome sequences from viremic patients with suspected dengue infection residing in two of the most-affected municipalities of São Paulo State, Araraquara and São José do Rio Preto. We conducted a comprehensive phylogenetic analysis with 1,630 global DENV strains to better understand the evolutionary history of the DENV lineages that currently circulate in the region. FINDINGS The new outbreak strains were classified as DENV2 genotype III (American/Asian genotype). Our analysis shows that the 2019 outbreak is the result of a novel DENV lineage that was recently introduced to Brazil from the Caribbean region. Dating phylogeographic analysis suggests that DENV2-III BR-4 was introduced to Brazil in or around early 2014, possibly from the Caribbean region. MAIN CONCLUSIONS Our study describes the early detection of a newly introduced and rapidly-expanding DENV2 virus lineage in Brazil.
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