Trial reportJournal of applied oral science : revista FOB2020
Effect of violet LED light on in-office bleaching protocols: a randomized controlled clinical trial.
Trial report in Journal of applied oral science : revista FOB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Comparative efficacy of violet light, bleaching gel, or their combination, in in-office bleaching: a systematic review and network meta-analysis.Brazilian oral research · 2026Pooled it
- Effect of the reduction in the exposure time to at-home bleaching gel on color change and tooth sensitivity: A systematic review and meta-analysis.Clinical oral investigations · 2024Pooled it
- Bleaching with biocatalysts and violet LED: a randomized clinical trial using a hybrid design with parallel-group and split-mouth approaches : Violet LED and biocatalysts in in-office whitening: a split-mouth trial.Clinical oral investigations · 2025Trial
- Does photobiomodulation before or after in-office dental bleaching influence sensitivity reduction? A randomized clinical trial.Lasers in medical science · 2025Trial
- Bleaching efficacy and tooth sensitivity using violet LED - single-blind randomized controlled trial.Lasers in medical science · 2025Trial
- Clinical performance of 6% hydrogen peroxide containing TiOLasers in medical science · 2022Trial
- Colorimetric evaluation after in-office tooth bleaching with violet LED: 6- and 12-month follow-ups of a randomized clinical trial.Clinical oral investigations · 2022Trial
- Effect of violet and blue light activation on in-office bleaching with 6% hydrogen peroxide: color change, penetration into the pulp chamber and bleaching gel stability.Lasers in medical science · 2026Article
- Effects of phthalimidoperoxycaproic acid (PAP+) associated or not with LED irradiation as a bleaching agent: an in vitro study.Lasers in medical science · 2026Article
- Evaluation of bleaching efficacy and cytotoxicity of an experimental hydrogel containing MnO-Doped Biosilicate® activated by violet LED light.Journal of applied oral science : revista FOB · 2026Article
- Evaluation of cytotoxicity and bleaching efficacy of gels with calcium polyphosphate and violet LED.Brazilian dental journal · 2026Article
- Article
- Hyaluronic Acid-Based Bleaching Gels With NF_TiOJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Article
- Characterization and effects on enamel of low-concentration bleaching gels containing hyaluronic acid, NF_TiOClinical oral investigations · 2025Article
- Enhanced tooth bleaching with a hydrogen peroxide/titanium dioxide gel.BMC oral health · 2024Article
- Low and high hydrogen peroxide concentrations of in-office dental bleaching associated with violet light: an in vitro study.Clinical oral investigations · 2024Article
- Catalysis-based approaches with biopolymers and violet LED to improve in-office dental bleaching.Lasers in medical science · 2024Article
- Impact of light activation on tooth whitening using three different light sources.Bioinformation · 2024Article
- Effectiveness of violet LED with or without a bleaching gel: a 12-month randomized clinical trial.Frontiers in dental medicine · 2024Article
- Effects of experimental bleaching gels containing co-doped titanium dioxide and niobium pentoxide combined with violet light.Clinical oral investigations · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective This study evaluated the clinical effect of violet LED light on in-office bleaching used alone or combined with 37% carbamide peroxide (CP) or 35% hydrogen peroxide (HP). Methodology A total of 100 patients were divided into five groups (n=20): LED, LED/CP, CP, LED/HP and HP. Colorimetric evaluation was performed using a spectrophotometer (ΔE, ΔL, Δa, Δb) and a visual shade guide (ΔSGU). Calcium (Ca)/phosphorous (P) ratio was quantified in the enamel microbiopsies. Measurements were performed at baseline (T 0 ), after bleaching (T B ) and in the 14-day follow-up (T 14 ). At each bleaching session, a visual scale determined the absolute risk (AR) and intensity of tooth sensitivity (TS). Data were evaluated by one-way (ΔE, Δa, ΔL, Δb), two-way repeated measures ANOVA (Ca/P ratio), and Tukey post-hoc tests. ΔSGU and TS were evaluated by Kruskal-Wallis and Mann-Whitney, and AR by Chi-Squared tests (a=5%). Results LED produced the lowest ΔE (p<0.05), but LED/HP promoted greater ΔE, ΔSGU and Δb (T 14 ) than HP (p<0.05). No differences were observed in ΔE and ΔSGU for LED/CP and HP groups (p>0.05). ΔL and Δa were not influenced by LED activation. After bleaching, LED/CP exhibited greater Δb than CP (p>0.05), but no differences were found between these groups at T 14 (p>0.05). LED treatment promoted the lowest risk of TS (16%), while HP promoted the highest (94.4%) (p<0.05). No statistical differences of risk of TS were found for CP (44%), LED/CP (61%) and LED/HP (88%) groups (p>0.05). No differences were found in enamel Ca/P ratio among treatments, regardless of evaluation times. Conclusions Violet LED alone produced the lowest bleaching effect, but enhanced HP bleaching results. Patients treated with LED/CP reached the same efficacy of HP, with reduced risk and intensity of tooth sensitivity and none of the bleaching protocols adversely affected enamel mineral content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.