ArticleNature2020
Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria.
Open access · greenAbstract read
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Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 89 citations in OpenAlex.
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Authors and funding
33 authors at 11 institutions in 4 countries.
Dipak K RajCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Alok Das MohapatraCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Anup JnawaliCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Jenna ZuromskiCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Ambrish JhaCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Gerald Cham-KpuCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Brett ShermanCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Rachel M RudlaffDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Christina E NixonCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Nicholas HiltonCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Andrew V OleinikovCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Olga ChesnokovCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Jordan MerrittCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Sunthorn Pond-TorCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Lauren BurnsCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Grant JollyDepartment of Pathology and Laboratory Medicine, Brown University Medical School, Providence, RI, USA.
Choukri Ben MamounDepartment of Internal Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5028-1400
Edward KabyemelaMother Offspring Malaria Studies (MOMS) Project, Seattle Biomedical Research Institute, Seattle, WA, USA.
Atis MuehlenbachsInfectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-1117-7357
Lynn LambertLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Sachy Orr-GonzalezLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Nina F GnädigDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
David A FidockDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6753-8938
Sangshin ParkCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.ORCID http://orcid.org/0000-0003-2407-0962
Jeffrey D DvorinDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Norbert PardiDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Drew WeissmanDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Barbara L MuiAcuitas Therapeutics, Vancouver, British Columbia, Canada.
Ying K TamAcuitas Therapeutics, Vancouver, British Columbia, Canada.
Jennifer F FriedmanCenter for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Michal Fried *Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Patrick E Duffy *Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-4483-5005
Jonathan D Kurtis *Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA. Jonathan_Kurtis@Brown.edu.
Brown University · USNational Institutes of Health · USFlorida Atlantic University · USAcuitas Therapeutics (Canada) · CABoston Children's Hospital · USColumbia University Irving Medical Center · USUniversity of Pennsylvania · USCenter for Infectious Disease Research · USCenters for Disease Control and Prevention · USUniversity of Seoul · KRYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTransgenic Mouse and Biobank CoreP01CA095616 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2003 to 2012
$20.3MMalaria Pathogenesis in young children and vaccine discoveryZIAAI001134 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2010 to 2025
$11.3MRole of pfcrt in chloroquine resistance in P. falciparumR01AI050234 · NIAID · YESHIVA UNIVERSITY · PI FIDOCK, DAVID A · 2001 to 2015
$5.7MCOBRE Center for Cancer Research DevelopmentP20GM103421 · NIGMS · RHODE ISLAND HOSPITAL · PI RAMRATNAM, BHARAT · 2012 to 2013
$4.5MDefining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4MTfh responses to novel vaccine candidates and protection from pediatric falciparum malariaR01AI127699 · NIAID · BROWN UNIVERSITY · PI KURTIS, JONATHAN D. · 2017 to 2021
$3.4MMolecular mechanisms of schizogony in malaria parasitesR01AI145941 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DVORIN, JEFFREY D · 2019 to 2023
$3.1MPfSEA-1 based vaccines for falciparum malariaR01AI110699 · NIAID · RHODE ISLAND HOSPITAL · PI KURTIS, JONATHAN D. · 2014 to 2018
$2.7MPathogenesis of falciparum malaria in infancyR01AI052059 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI DUFFY, PATRICK E · 2001 to 2004
$2.7MTargeted Vaccine Development for Pediatric Falciparum MalariaR01AI076353 · NIAID · RHODE ISLAND HOSPITAL · PI KURTIS, JONATHAN D. · 2008 to 2011
$2.4MMolecular characterization and substrate identification of malaria kinase PfCDPK5R01AI102907 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DVORIN, JEFFREY D · 2014 to 2017
$1.8MNCATS NIH HHS UL1 TR001863NCI NIH HHS P01 CA095616NIAID NIH HHS R01 AI050234NIAID NIH HHS R01 AI052059NIAID NIH HHS R01 AI076353NIAID NIH HHS R01 AI092120NIAID NIH HHS R01 AI102907NIAID NIH HHS R01 AI110699NIAID NIH HHS R01 AI127699NIAID NIH HHS R01 AI145941NIAID NIH HHS R37 AI050234NIGMS NIH HHS P20 GM103421NIH HHS S10 OD023461
Abstract
Malaria caused by Plasmodium falciparum remains the leading single-agent cause of mortality in children
Indexed as
AdolescentAdultAnimalsAntibodies, ProtozoanAntigens, ProtozoanAotidaeApoptosisCaspasesChildCohort StudiesDNA, ProtozoanEnzyme ActivationErythrocytesFemaleHumansIntercellular Signaling Peptides and ProteinsAntibodies, ProtozoanAntigens, ProtozoanCaspasesDNA, ProtozoanGARP protein, Plasmodium falciparumIntercellular Signaling Peptides and ProteinsMalaria VaccinesProtozoan Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.