ArticleScientific reports2020
Clues of in vivo nuclear gene regulation by mitochondrial short non-coding RNAs.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Small but mighty: mitochondrial DNA at the centre of retrograde signalling.Cell communication and signaling : CCS · 2026Review
- SmithRNAs: A Common Feature among Metazoa.Genome biology and evolution · 2025Article
- Hybridization and gene expression: Beyond differentially expressed genes.Molecular ecology · 2025Review
- Assembly and comparative analysis of the complete mitochondrial genome of the spice plant Cinnamomum longepaniculatum.BMC plant biology · 2025Article
- SmithHunter: a workflow for the identification of candidate smithRNAs and their targets.BMC bioinformatics · 2024Article
- Mitochondrion-to-nucleus communication mediated by RNA export: a survey of potential mechanisms and players across eukaryotes.Biology letters · 2024Review
- Mitochondrially mediated RNA interference, a retrograde signaling system affecting nuclear gene expression.Heredity · 2024Article
- Mitonuclear Sex Determination? Empirical Evidence from Bivalves.Molecular biology and evolution · 2023Article
- Unraveling mitochondrial piRNAs in mouse embryonic gonadal cells.Scientific reports · 2022Article
- Complex mitogenomic rearrangements within the Pectinidae (Mollusca: Bivalvia).BMC ecology and evolution · 2022Article
- Article
- Mitochondrial Short-Term Plastic Responses and Long-Term Evolutionary Dynamics in Animal Species.Genome biology and evolution · 2021Review
- Molluscan mitochondrial genomes break the rules.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene expression involves multiple processes, from transcription to translation to the mature, functional peptide, and it is regulated at multiple levels. Small RNA molecules are known to bind RNA messengers affecting their fate in the cytoplasm (a process generically termed 'RNA interference'). Such small regulatory RNAs are well-known to be originated from the nuclear genome, while the role of mitochondrial genome in RNA interference was largely overlooked. However, evidence is growing that mitochondrial DNA does provide the cell a source of interfering RNAs. Small mitochondrial highly transcribed RNAs (smithRNAs) have been proposed to be transcribed from the mitochondrion and predicted to regulate nuclear genes. Here, for the first time, we show in vivo clues of the activity of two smithRNAs in the Manila clam, Ruditapes philippinarum. Moreover, we show that smithRNAs are present and can be annotated in representatives of the three main bilaterian lineages; in some cases, they were already described and assigned to a small RNA category (e.g., piRNAs) given their biogenesis, while in other cases their biogenesis remains unclear. If mitochondria may affect nuclear gene expression through RNA interference, this opens a plethora of new possibilities for them to interact with the nucleus and makes metazoan mitochondrial DNA a much more complex genome than previously thought.
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