ArticleScientific reports2020
3D Bioprinting of osteochondral tissue substitutes - in vitro-chondrogenesis in multi-layered mineralized constructs.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 126 citations in OpenAlex.
- Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction.Bioactive materials · 2027Review
- Functional Biomaterials and 3D Bioprinting Approaches for Temporomandibular Joint Reconstruction: A Narrative Review.Journal of functional biomaterials · 2026Review
- Predicting Cell Differentiation in Mechanically Stimulated Biphasic Osteochondral Scaffolds Using Fluid-Structure Interaction Modelling.Bioengineering (Basel, Switzerland) · 2026Article
- Enhancing bioactivity of 3D-printed porous scaffolds with self-assembling peptide hydrogels for cartilage tissue engineering.3D printing in medicine · 2026Article
- Biphasic Bone Implants through Hybrid Extrusion Printing of Thermoplastic Poly(lactic-ACS omega · 2026Article
- Innovative prospects in 3D printed bio-scaffolds for osteochondral tissue engineering: A systematic review.World journal of methodology · 2026Article
- 3D-Printed Biohybrid PE/PCL Biphasic Osteochondral Plug for Knee Cartilage Repair.ACS materials Au · 2026Article
- Functionally Graded Surfaces and Materials: From Fabrication to Biomedical Applications.Chemical reviews · 2026Review
- 3D Printing of Bacteriophage-Loaded Hydrogels: Development of a Local and Long-Lasting Delivery System.Advanced healthcare materials · 2026Article
- Optimized gradient of lyophilized platelet-rich plasma in biomimetic 3D-printed triphasic scaffold based on alginate and gelatin for osteochondral tissue engineering.Scientific reports · 2026Article
- Stem Cell and Cell-Free Strategies for Osteoarthritis: Toward Durable Regenerative Therapies.Stem cells international · 2026Review
- Additive manufacturing - an antidote to bottlenecks in tissue engineering and regenerative medicine.Frontiers in bioengineering and biotechnology · 2026Review
- Modular de- and re-construction of vascularized osteochondral tissues in an Organ-on-Chip dual-compartment platform.Journal of orthopaedic translation · 2026Article
- Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research?Bioactive materials · 2025Review
- Intelligent Manufacturing for Osteoarthritis Organoids.Cell proliferation · 2025Review
- Additive manufacturing of patient-specific, biphasic implants with zonal design for regeneration of osteochondral defects-critical evaluation of the work flow from clinical MRI data to implantation.Materials today. Bio · 2025Article
- Strategic Implementation of Multimaterial Additive Manufacturing: Bridging Research and Real-World Applications.ACS omega · 2025Review
- Novel Protein-Rich Bioactive Bioink Stimulates Cellular Proliferation and Response in 3D Bioprinted Volumetric Constructs.Advanced healthcare materials · 2025Article
- Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review.Bioactive materials · 2025Review
- Engineering gene-activated bioprinted scaffolds for enhancing articular cartilage repair.Materials today. Bio · 2024Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the generation of multi-layered full thickness osteochondral tissue substitutes with an individual geometry based on clinical imaging data, combined extrusion-based 3D printing (3D plotting) of a bioink laden with primary chondrocytes and a mineralized biomaterial phase was introduced. A pasty calcium phosphate cement (CPC) and a bioink based on alginate-methylcellulose (algMC) - both are biocompatible and allow 3D plotting with high shape fidelity - were applied in monophasic and combinatory design to recreate osteochondral tissue layers. The capability of cells reacting to chondrogenic biochemical stimuli inside the algMC-based 3D hydrogel matrix was assessed. Towards combined osteochondral constructs, the chondrogenic fate in the presence of CPC in co-fabricated and biphasic mineralized pattern was evaluated. Majority of expanded and algMC-encapsulated cells survived the plotting process and the cultivation period, and were able to undergo redifferentiation in the provided environment to produce their respective extracellular matrix (ECM) components (i.e. sulphated glycosaminoglycans, collagen type II), examined after 3 weeks. The presence of a mineralized zone as located in the physiological calcified cartilage region suspected to interfere with chondrogenesis, was found to support chondrogenic ECM production by altering the ionic concentrations of calcium and phosphorus in in vitro culture conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.