Evidence map›Paper›PMID 32427721›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2020

Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV.

Shanti M Seaman, Sarah E Van Pilsum Rasmussen, Anh Q Nguyen, Samantha E Halpern, Susan You, Madeleine M Waldram, Saad K Anjum, Mary Grace Bowring, Abimereki D Muzaale, Darin B Ostrander and 20 more

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Post-transplant survey to assess patient experiences with donor-derived HCV infection.Transplant infectious disease : an official journal of the Transplantation Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 11 institutions in 1 country.

Shanti M SeamanDepartments of Medicine; and.
Sarah E Van Pilsum RasmussenSurgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Anh Q NguyenDepartments of Medicine; and.
Samantha E HalpernSurgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Susan YouDepartments of Medicine; and.
Madeleine M WaldramDepartments of Medicine; and.
Saad K AnjumSurgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Mary Grace BowringSurgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Abimereki D MuzaaleSurgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Darin B OstranderDepartments of Medicine; and.
Diane BrownDepartments of Medicine; and.
Allan B MassieSurgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Aaron A R TobianDepartments of Medicine; and.
Macey L HendersonSurgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Faith E FletcherDepartment of Health Behavior, University of Alabama at Birmingham School of Public Health, Birmingham, AL.
Burke SmithDepartment of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL.
Ada ChaoDepartments of Surgery; and.
Nishita GorupatiDepartments of Surgery; and.
Katya PrakashMedicine, University of California San Diego, San Diego, CA.
Saima AslamMedicine, University of California San Diego, San Diego, CA.
Dong H LeeDepartment of Medicine, Drexel University College of Medicine, Philadelphia, PA.
Varvara KirchnerDepartment of Surgery, University of Minnesota, Minneapolis, MN.
Timothy L PruettDepartment of Surgery, University of Minnesota, Minneapolis, MN.
Ghady HaidarDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Kailey HughesDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Maricar MalinisSection of Infectious Diseases, Yale University School of Medicine, New Haven, CT.
Sonya TrinhDepartment of Medicine, Ochsner Clinic Foundation, New Orleans, LA; and.
Dorry L SegevSurgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Jeremy SugarmanDepartments of Medicine; and.
Christine M DurandDepartments of Medicine; and.
Johns Hopkins Medicine · USJohns Hopkins University · USUniversity of Alabama at Birmingham · USUniversity of California, San Diego · USUniversity of Minnesota · USUniversity of Pittsburgh · USDrexel University · USJohns Hopkins Berman Institute of Bioethics · USOchsner Medical Center · USUniversity of Florida · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
HOPE in Action: A Clinical Trial of HIV-to-HIV Liver TransplantationU01AI138897 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2018 to 2026
$25.5M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
HOPE in Action: A clinical trial of HIV-to-HIV deceased donor kidney transplantationU01AI134591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE, SEGEV, DORRY L. · 2017 to 2021
$11.0M
Unlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Optimal Antiretroviral Therapy During Bone Marrow Transplant in HIV-1 InfectionK23CA177321 · NCI · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE · 2014 to 2018
$808k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K23 CA177321NIAID NIH HHS K24 AI144954NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI120938NIAID NIH HHS U01 AI134591NIAID NIH HHS U01 AI138897NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K24 DK101828NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

backgroundHIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access to transplantation for people living with HIV. However, it remains unknown whether transplant candidates living with HIV will accept the currently unknown risks of HIV D+/R+ transplantation.

methodsWe surveyed transplant candidates living with HIV from 9 US transplant centers regarding willingness to accept HIV+ donor organs.

resultsAmong 116 participants, the median age was 55 years, 68% were men, and 78% were African American. Most were willing to accept HIV+ living donor organs (87%), HIV+ deceased donor organs (84%), and increased infectious risk donor organs (70%). Some (30%) were concerned about HIV superinfection; even among these respondents, 71% were willing to accept an HIV D+ organ. Respondents from centers that had already performed a transplant under an HIV D+/R+ transplantation research protocol were more willing to accept HIV+ deceased donor organs (89% vs. 71%, P = 0.04). Respondents who chose not to enroll in an HIV D+/R+ transplantation research protocol were less likely to believe that HIV D+/R+ transplantation was safe (45% vs. 77%, P = 0.02), and that HIV D+ organs would work similar to HIV D- organs (55% vs. 77%, P = 0.04), but more likely to believe they would receive an infection other than HIV from an HIV D+ organ (64% vs. 13%, P < 0.01).

conclusionsWillingness to accept HIV D+ organs among transplant candidates living with HIV does not seem to be a major barrier to HIV D+/R+ transplantation and may increase with growing HIV D+/R+ transplantation experience.

Indexed as

HIV-1Tissue DonorsTransplant RecipientsFemaleHIV InfectionsHumansMaleMiddle AgedOrgan TransplantationRisk FactorsTransplants

Identifiers

PMID32427721
PMCPMC7429320
OpenAlexW3026433598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.