Evidence map›Paper›PMID 32427720›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2020

Brief Report: Incidence and Correlates of Pregnancy in HIV-Positive Kenyan Sex Workers.

Erica M Lokken, George Wanje, Barbra A Richardson, Esther Mutunga, Kate S Wilson, Walter Jaoko, John Kinuthia, Raymond Scott McClelland

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Erica M LokkenDepartment of Epidemiology, University of Washington, Seattle, WA.
George WanjeDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
Barbra A RichardsonDepartment of Biostatistics, University of Washington, Seattle, WA.
Esther MutungaDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
Kate S WilsonDepartment of Global Health, University of Washington, Seattle, WA.
Walter JaokoDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
John KinuthiaObstetrics and Gynaecology, Kenyatta National Hospital, Nairobi, Kenya.
Raymond Scott McClellandDepartment of Epidemiology, University of Washington, Seattle, WA.
University of Washington · USUniversity of Nairobi · KEKenyatta National Hospital · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
Innate immune determinants of HIV rebound and persistenceR01HD103571 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JULIE M. OVERBAUGH · 2020 to 2026
$6.7M
Women's Life Events & HIV Transmission Potential: A Multidisciplinary StudyR01HD072617 · NICHD · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, RAYMOND SCOTT · 2012 to 2016
$2.1M
RCT of an Implementation Science Tool to Integrate HIV testing into Family Planning Services K24HD088229 · NICHD · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, RAYMOND SCOTT · 2016 to 2020
$863k
NIAID NIH HHS P30 AI027757NIAID NIH HHS T32 AI007140NICHD NIH HHS K24 HD088229NICHD NIH HHS R01 HD072617NICHD NIH HHS R01 HD103571
6 · The paper itself

Abstract

introductionThe incidence of pregnancy in female sex workers (FSWs) living with HIV is not well characterized.

methodsCurrent and former FSWs living with HIV and enrolled in a prospective cohort study in Mombasa, Kenya, were followed monthly to ascertain sexual behavior and underwent quarterly pregnancy testing. Pregnancies were considered planned, mistimed, or unwanted according to fertility desires and pregnancy intentions. Cox proportional hazards models were used to estimate hazard ratios (HRs) of the association between characteristics and incident pregnancy.

resultsTwo hundred seventy-nine FSWs were eligible (October 2012-April 2017). Most women had a nonpaying, regular partner (83.2%, 232/279), were not using modern nonbarrier contraception (69.5%, 194/279), and did not desire additional children (70.6%, 197/279). Of 34 first incident pregnancies [5.8/100 person-years (p-y); 95% confidence interval (CI): 4.1 to 8.0], 91.2% (n = 31) were unintended. The incidences of planned (5.7/100 p-y, n = 3), mistimed (10.4/100 p-y, n = 9), and unwanted pregnancies (4.9/100 p-y, n = 22) were similar (P = 0.15). In univariable analysis, oral contraceptive pill use (versus no contraception), having a nonpaying, regular partner, transactional sex, vaginal washing, condomless sex, and higher sex frequency were associated with an increased pregnancy risk. Older age was associated with a lower pregnancy risk. In multivariable analysis, having a nonpaying, regular partner (adjusted HR 4.0, 95% CI: 1.2 to 14.1) and age ≥40 years (aHR 0.2, 95% CI: 0.0 to 0.9) remained significantly associated with a higher and lower pregnancy risk, respectively.

conclusionIn this cohort of HIV-positive FSWs, most pregnancies were unintended. Identifying FSWs' fertility desires and pregnancy intentions could facilitate efforts to increase contraceptive use and implement safer conception strategies.

Indexed as

Sex WorkersAdultContraception BehaviorFemaleHIV InfectionsHumansIncidenceKenyaPregnancyPregnancy Complications, InfectiousRisk FactorsYoung Adult

Identifiers

PMID32427720
PMCPMC7885713
OpenAlexW3026690067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.