ArticleAmerican journal of physical medicine & rehabilitation2020
Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation.
Article in American journal of physical medicine & rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of in vivo stretching regimens on inflammation and its relevance to translational yoga research.PloS one · 2022Pooled it
- Pooled it
- The Science of Tai Chi andJournal of integrative and complementary medicine · 2025Review
- Effect of stretching on inflammation in a subcutaneous carrageenan mouse model analyzed at single-cell resolution.Journal of cellular physiology · 2023Article
- Mechanisms Underlying Anti-Inflammatory and Anti-Cancer Properties of Stretching-A Review.International journal of molecular sciences · 2022Review
- Plasma proteome responses in zebrafish following λ-carrageenan-Induced inflammation are mediated by PMN leukocytes and correlate highly with their human counterparts.Frontiers in immunology · 2022Article
- The Effects of a Single Bout of High- or Moderate-Intensity Yoga Exercise on Circulating Inflammatory Mediators: A Pilot Feasibility Study.Global advances in health and medicine · 2022Article
- Myofascial Injection Using Fascial Layer-Specific Hydromanipulation Technique (FLuSH) and the Delineation of Multifactorial Myofascial Pain.Medicina (Kaunas, Lithuania) · 2020Article
- Persistent Relief: Protocol for a Feasibility Randomized Trial Comparing Yoga to Pain Education for Patients With Persistent Post-Surgical Pain.Global advances in integrative medicine and healthArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveActive stretching of the body is integral to complementary mind-body therapies such as yoga, as well as physical therapy, yet the biologic mechanisms underlying its therapeutic effects remain largely unknown. A previous study showed the impact of active stretching on inflammatory processes in rats. The present study tested the feasibility of using a porcine model, with a closer resemblance to human anatomy, to study the effects of active stretching in the resolution of localized inflammation.
designA total of 12 pigs were trained to stretch before subcutaneous bilateral Carrageenan injection in the back at the L3 vertebrae, 2 cm from the midline. Animals were randomized to no-stretch or stretch, twice a day for 5 mins over 48 hrs. Animals were euthanized for tissue collection 48 hrs postinjection.
resultsThe procedure was well tolerated by the pigs. On average, lesion area was significantly smaller by 36% in the stretch group compared with the no-stretch group (P = 0.03).
conclusionThis porcine model shows promise for studying the impact of active stretching on inflammation-resolution mechanisms. These results are relevant to understanding the stretching-related therapeutic mechanisms of mind-body therapies. Future studies with larger samples are warranted.
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