ArticleJournal of clinical hypertension (Greenwich, Conn.)2020
The cumulative blood pressure load and target organ damage in patients with essential hypertension.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Cumulative blood pressure and risk of dementia and cognitive decline: a systematic review and meta-analysis.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Machine Learning in Left Ventricular Hypertrophy Detection: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Associations of Ambulatory Blood Pressure Measurements With High-Sensitivity Troponin and Natriuretic Peptide Levels in SPRINT.American journal of hypertension · 2024Trial
- Qianyang Yuyin granule modulates glycolysis and inflammatory response to treat hypertensive cardiac remodeling.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Ambulatory blood pressure monitoring in arterial hypertension.Internal and emergency medicine · 2026Review
- The global burden of hypertension and its epidemiological impacts on adolescents and young adults: projections to 2050.Frontiers in cardiovascular medicine · 2025Article
- The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients.Open medicine (Warsaw, Poland) · 2025Article
- Risk factors and a predictive model for left ventricular hypertrophy in young adults with salt-sensitive hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Association between baseline blood pressure variability and left heart function following short-term extreme cold exposure.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- The effects of obstructive sleep apnea on blood pressure variability and load in patients with hypertension.Sleep & breathing = Schlaf & Atmung · 2024Article
- Association of Variability and Hypertensive Loads in 24-h Blood Pressure With Mortality and Cardiovascular Risk.American journal of hypertension · 2024Article
- Ambulatory blood pressure levels in individuals with uncontrolled clinic hypertension across Bangladesh, Pakistan, and Sri Lanka.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Cumulative blood pressure load and hypertensive nephropathy in Han Chinese hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Time-weighted blood pressure with cardiovascular risk among patients with or without diabetes.Clinical cardiology · 2024Article
- The Role of Blood Pressure Load in Ambulatory Blood Pressure Monitoring in Adults: A Literature Review of Current Evidence.Diagnostics (Basel, Switzerland) · 2023Review
- Cumulative hypertension burden and risk of end-stage renal disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Correlation between serum miR-122 and myocardial damage and ventricular function in patients with essential hypertension.Journal of thoracic disease · 2021Article
- Blood Pressure Load: An Effective Indicator of Systemic Circulation Status in Individuals With Acute Altitude Sickness.Frontiers in cardiovascular medicine · 2021Article
- The role of smoking cessation programs in lowering blood pressure: A retrospective cohort study.Tobacco induced diseases · 2021Article
- The cumulative blood pressure load and target organ damage in patients with essential hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The area under the blood pressure curve is associated with target organ damage, but accurately estimating its value is challenging. This study aimed to improve the utility of the area under the blood pressure curve to predict hypertensive target organ damage. This retrospective cohort study comprised of 634 consecutive patients with essential hypertension for >1 year. Target organ damage was defined as the presence of left ventricular hypertrophy and/or carotid artery plaques. We evaluated the associations between the cumulative blood pressure load, which was derived from ambulatory blood pressure monitoring data, and target organ damage. The predictive value of the cumulative blood pressure load for target organ damage was assessed using receiver operating characteristic curves. Left ventricular hypertrophy and carotid artery plaques were present in 392 (61.8%) and 316 (49.8%) patients, respectively. Patients with left ventricular hypertrophy and/or carotid artery plaques had higher 24-hour blood pressure, nocturnal cumulative systolic blood pressure, and nocturnal cumulative pulse pressure load. The nocturnal cumulative systolic blood pressure load was an independent predictor of left ventricular hypertrophy (odds ratio = 1.002, 95% confidence interval: 1.001-1.004; P = .000) and carotid artery plaques (odds ratio = 1.003, 95% confidence interval: 1.002-1.007; P = .007). The nocturnal cumulative systolic blood pressure and cumulative pulse pressure load, relative to mean blood pressure, were superior in predicting hypertensive target organ damage. Hence, the cumulative blood pressure load is a better indicator of blood pressure consequences, and the nocturnal cumulative systolic blood pressure and cumulative pulse pressure loads could predict target organ damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.