ArticleAging2020
Age-related cognitive decline in baboons: modeling the prodromal phase of Alzheimer's disease and related dementias.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- The Baboon as a Model to Study Human Health and Complex Disease.American journal of primatology · 2026Review
- Inflammation from mild COVID-19 results in persistent neurological and behavioral changes in rhesus macaques.Research square · 2025Article
- Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed.Neurobiology of aging · 2025Article
- Assessment of Oxidative Stress and Biometric Data in a Captive Colony of Hamadryas Baboons (Veterinary sciences · 2025Article
- Article
- Characterizing plasma and cerebrospinal fluid biomarkers relevant to neurodegeneration in captive olive baboons (Papio anubis).PloS one · 2025Article
- Review
- Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed.bioRxiv : the preprint server for biology · 2024Article
- Neutrophil to lymphocyte ratio in captive olive baboons (Papio anubis): The effects of age, sex, rearing, stress, and pregnancy.American journal of primatology · 2024Article
- Development and assessment of a stair ascension challenge as a measure of aging and physical function in nonhuman primates.American journal of primatology · 2024Article
- Amyloid-β Pathology Is the Common Nominator Proteinopathy of the Primate Brain Aging.Journal of Alzheimer's disease : JAD · 2024Review
- Age-associated alterations in immune and inflammatory responses in captive olive baboons (Frontiers in aging · 2024Article
- Opioid abuse and SIV infection in non-human primates.Journal of neurovirology · 2023Review
- Age- and sex-related differences in baboon (Papio anubis) gray matter covariation.Neurobiology of aging · 2023Article
- Age-Related Learning and Working Memory Impairment in the Common Marmoset.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Review
- Apex and ApeTouch: Development of a Portable Touchscreen System and Software for Primates at Zoos.Animals : an open access journal from MDPI · 2022Article
- Comparative neuropathology in aging primates: A perspective.American journal of primatology · 2021Review
- Longitudinal MRI template of the baboon brain from birth to adolescence.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The aging of brain cells and synaptic loss are the major underlying pathophysiological processes contributing to the progressive decline in cognitive functions and Alzheimer's disease. The difference in cognitive performances observed between adult and aged subjects across species highlights the decline of brain systems with age. The inflection point in age-related cognitive decline is important for our understanding of the pathophysiology of neurodegenerative diseases and for timing therapeutic interventions. Humans and nonhuman primates share many similarities including age-dependent changes in gene expression and decline in neural and immune functions. Given these evolutionary conserved organ systems, complex human-like behavioral and age-dependent changes may be modeled and monitored longitudinally in nonhuman primates. We integrated three clinically relevant outcome measures to investigate the effect of age on cognition, motor function and diurnal activity in aged baboons. We provide evidence of a naturally-occurring age-dependent precipitous decline in movement planning, in learning novel tasks, in simple discrimination and in motivation. These results suggest that baboons aged ~20 years (equivalent to ~60 year old humans) may offer a relevant model for the prodromal phase of Alzheimer's disease and related dementias to investigate mechanisms involved in the precipitous decline in cognitive functions and to develop early therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.