Evidence map›Paper›PMID 32426812›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Reduction of Coronavirus Burden With Mass Azithromycin Distribution.

Thuy Doan, Armin Hinterwirth, Ahmed M Arzika, Lee Worden, Cindi Chen, Lina Zhong, Catherine E Oldenburg, Jeremy D Keenan, Thomas M Lietman

Registry-linked trialAbstract readClinical Trial, Phase IVRandomized Controlled Trial
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02047981 (Evaluating Impact of Azithromycin Mass Drug Administrations on All-cause Mortality and Antibiotic Resistance), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02047981 phase4completednot on this map

Evaluating Impact of Azithromycin Mass Drug Administrations on All-cause Mortality and Antibiotic Resistance: Mortality Trial

TypeinterventionalSponsorUniversity of California, San FranciscoRan2014 to 2018Enrolled190,238ConditionsChildhood MortalityArmsAzithromycin, Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Beneficial ex vivo immunomodulatory and clinical effects of clarithromycin in COVID-19.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022
    Article
  4. A determination of pan-pathogen antimicrobials?Medicine in drug discovery · 2022
    Review
  5. Review
  6. Review
  7. Azithromycin in viral infections.Reviews in medical virology · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thuy DoanFrancis I. Proctor Foundation, San Francisco, California, USA.
Armin HinterwirthFrancis I. Proctor Foundation, San Francisco, California, USA.
Ahmed M ArzikaCarter Center, Niamey, Niger.
Lee WordenFrancis I. Proctor Foundation, San Francisco, California, USA.
Cindi ChenFrancis I. Proctor Foundation, San Francisco, California, USA.
Lina ZhongFrancis I. Proctor Foundation, San Francisco, California, USA.
Catherine E OldenburgFrancis I. Proctor Foundation, San Francisco, California, USA.
Jeremy D KeenanFrancis I. Proctor Foundation, San Francisco, California, USA.
Thomas M LietmanFrancis I. Proctor Foundation, San Francisco, California, USA.

Funding

The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
Ocular Surface Microbiome, Virome, and Pathogens in Ophthalmic Disease and HealthK08EY026986 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DOAN, THUY A · 2016 to 2020
$1.2M
NEI NIH HHS K08 EY026986NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

We evaluated the potential antiviral effects of azithromycin on the nasopharyngeal virome of Nigerien children who had received multiple rounds of mass drug administration. We found that the respiratory burden of non-severe acute respiratory syndrome coronaviruses was decreased with azithromycin distributions. Clinical Trials Registration. NCT02047981.

Indexed as

Mass Drug AdministrationAdministration, OralAntiviral AgentsAzithromycinChild, PreschoolCoronavirusCoronavirus InfectionsHumansInfantInfant, NewbornNasopharynxNigeriaViral LoadAntiviral AgentsAzithromycinazithromycinchildrencoronavirusNigervirome

Identifiers

PMID32426812
PMCPMC7314118

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.