ArticleScience advances2020
Topology control of human fibroblast cells monolayer by liquid crystal elastomer.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 133 citations in OpenAlex.
- Fibronectin matrix remodelling modulates the active nematic dynamics of cancer-associated fibroblasts.Nature materials · 2026Article
- Engineering and Exploring Hydrolytic Degradation in 3D-Printed Liquid Crystalline Elastomers.Biomacromolecules · 2026Article
- An Amino-Yne Click Chemistry Approach for Multi-Responsive Liquid Crystal Elastomer Actuators.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Shaping 3D minimal model tissues with mechanical constraints to orchestrate muscle differentiation.Communications biology · 2025Article
- Anisotropic liquid crystalline hydrogels direct 2D and 3D myoblast alignment.Advanced functional materials · 2025Article
- Light-Responsive Liquid Crystal Surface Topographies for Dynamic Stimulation of Cells.ACS applied materials & interfaces · 2025Article
- Integer topological defects offer a methodology to quantify and classify active cell monolayers.Nature communications · 2025Article
- Tumoroids, a valid preclinical screening platform for monitoring cancer angiogenesis.Stem cell research & therapy · 2024Review
- Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment.Science advances · 2024Article
- Machine learning topological defects in confluent tissues.Biophysical reports · 2024Article
- Article
- Soft-Matter Physics Provides New Insights on Myocardial Architecture: Automatic and Quantitative Identification of Topological Defects in the Trabecular Myocardium.Journal of cardiovascular development and disease · 2023Article
- Programming Deformations of 3D Microstructures: Opportunities Enabled by Magnetic Alignment of Liquid Crystalline Elastomers.Accounts of materials research · 2023Article
- Improvement of Intracellular Interactions through Liquid Crystalline Elastomer Scaffolds by the Alteration of Topology.ACS omega · 2023Article
- Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density.Nature communications · 2023Article
- Self-healing and shape-shifting polymers controlled by dynamic bonds.Smart molecules : open access · 2023Review
- Molecular-scale substrate anisotropy, crowding and division drive collective behaviours in cell monolayers.Journal of the Royal Society, Interface · 2023Article
- Patterning of morphogenetic anisotropy fields.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Instantaneous mapping of liquid crystal orientation using a polychromatic polarizing microscope.Liquid crystals · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic cells in living tissues form dynamic patterns with spatially varying orientational order that affects important physiological processes such as apoptosis and cell migration. The challenge is how to impart a predesigned map of orientational order onto a growing tissue. Here, we demonstrate an approach to produce cell monolayers of human dermal fibroblasts with predesigned orientational patterns and topological defects using a photoaligned liquid crystal elastomer (LCE) that swells anisotropically in an aqueous medium. The patterns inscribed into the LCE are replicated by the tissue monolayer and cause a strong spatial variation of cells phenotype, their surface density, and number density fluctuations. Unbinding dynamics of defect pairs intrinsic to active matter is suppressed by anisotropic surface anchoring allowing the estimation of the elastic characteristics of the tissues. The demonstrated patterned LCE approach has potential to control the collective behavior of cells in living tissues, cell differentiation, and tissue morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.