Evidence map›Paper›PMID 32426466›Full record

ArticleScience advances2020

An ultraportable and versatile point-of-care DNA testing platform.

Huan Xu, Anyue Xia, Dandan Wang, Yiheng Zhang, Shaoli Deng, Weiping Lu, Jie Luo, Qiu Zhong, Fengling Zhang, Lin Zhou and 9 more

Abstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  16. Article
  17. Rapid Detection ofJournal of microbiology and biotechnology · 2022
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Huan XuDepartment of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID 0000-0002-6274-908X
Anyue XiaFirst Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210029, China.
Dandan WangCAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.
Yiheng ZhangCentral Laboratory, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Shaoli DengDepartment of Clinical Laboratory Medicine, Institute of Surgery Research, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing 400042, China.
Weiping LuDepartment of Clinical Laboratory Medicine, Institute of Surgery Research, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing 400042, China.
Jie LuoDepartment of Clinical Laboratory, The 954th Hospital of Chinese People's Liberation Army, Xizang 856000, China.
Qiu ZhongDepartment of Clinical Laboratory Medicine, Institute of Surgery Research, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing 400042, China.
Fengling ZhangDepartment of Clinical Laboratory Medicine, Institute of Surgery Research, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing 400042, China.
Lin ZhouDepartment of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID 0000-0002-1082-3225
Wenqing ZhangDepartment of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Yang WangDepartment of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Cheng YangDepartment of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Kai ChangDepartment of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID 0000-0001-7587-3066
Weiling FuDepartment of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Jinhui CuiCAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.ORCID 0000-0003-0172-8709
Mingzhe GanCAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.ORCID 0000-0003-0183-400X
Dan LuoDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-1236-4069
Ming ChenDepartment of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID 0000-0003-0613-7932

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Point-of-care testing (POCT) has broad applications in resource-limited settings. Here, a POCT platform termed POCKET (point-of-care kit for the entire test) is demonstrated that is ultraportable and versatile for analyzing multiple types of DNA in different fields in a sample-to-answer manner. The POCKET is less than 100 g and smaller than 25 cm in length. The kit consists of an integrated chip (i-chip) and a foldable box (f-box). The i-chip integrates the sample preparation with a previously unidentified, triple signal amplification. The f-box uses a smartphone as a heater, a signal detector, and a result readout. We detected different types of DNA from clinics to environment to food to agriculture. The detection is sensitive (<10

Indexed as

Point-of-Care SystemsPoint-of-Care TestingDNASmartphoneDNA

Identifiers

PMID32426466
PMCPMC7176422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.