ArticleFrontiers in pediatrics2020
Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Frontiers in pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 20 citations in OpenAlex.
- Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life.Journal of immunology research · 2024Trial
- Newborns with sickle cell trait have distinct peripheral blood molecular signatures across the first week of life.Blood. Red cells & iron · 2026Article
- Population-specific heterogeneity in ontogeny of the broadly-conserved blood transcriptional program during the first week of life.Nature communications · 2026Article
- A randomized prospective study of neonatal hepatitis B vaccine immunogenicity in The Gambia and Papua New Guinea.The journal of allergy and clinical immunology. Global · 2026Article
- Higher Promoter Methylation of the Ubiquitin-Associated and SH3 Domain Containing A (UBASH3A) Gene Is Associated With T-Lymphocyte Ontogeny and Reduced Susceptibility to Early-Onset Sepsis.The Journal of infectious diseases · 2026Article
- Immune Development in Early Life (IDEaL) longitudinal cohort study protocol: Identifying biomarkers of vaccine responsiveness, respiratory infection, and asthma.The journal of allergy and clinical immunology. Global · 2025Article
- Report of a SPEAC webinar 22 september 2023: Sensorineural hearing loss, lassa virus disease and vaccines.Vaccine · 2025Review
- Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation.EBioMedicine · 2024Article
- DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life.Nature communications · 2024Observational
- Plasma adenosine deaminase-1 and -2 activities are lower at birth in Papua New Guinea than in The Gambia but converge over the first weeks of life.Frontiers in immunology · 2024Article
- flowSim: Near duplicate detection for flow cytometry data.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2023Article
- A single birth dose of Hepatitis B vaccine induces polyfunctional CD4Frontiers in immunology · 2022Article
- Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life.Cytokine · 2021Article
- Searching for a technology-driven acute rheumatic fever test: the START study protocol.BMJ open · 2021Article
- Conducting clinical research in a resource-constrained setting: lessons from a longitudinal cohort study in The Gambia.BMJ global health · 2021Article
- Review
- Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life.Frontiers in immunology · 2021Article
- Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections.Metabolites · 2020Review
- A cloud-based bioinformatic analytic infrastructure and Data Management Core for the Expanded Program on Immunization Consortium.Journal of clinical and translational science · 2020Article
- Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life.Frontiers in immunology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
26 authors at 11 institutions in 7 countries.
Olubukola T IdokoVaccines and Immunity Theme, Medical Research Council Unit the Gambia at London School of Hygiene and Tropical Medicine, Fajara, Gambia.
Kinga K SmolenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Oghenebrume WaririVaccines and Immunity Theme, Medical Research Council Unit the Gambia at London School of Hygiene and Tropical Medicine, Fajara, Gambia.
Abdulazeez ImamVaccines and Immunity Theme, Medical Research Council Unit the Gambia at London School of Hygiene and Tropical Medicine, Fajara, Gambia.
Casey P ShannonPROOF Centre of Excellence, Vancouver, BC, Canada.
Tida DibasseyVaccines and Immunity Theme, Medical Research Council Unit the Gambia at London School of Hygiene and Tropical Medicine, Fajara, Gambia.
Joann Diray-ArcePrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Alansana DarboeVaccines and Immunity Theme, Medical Research Council Unit the Gambia at London School of Hygiene and Tropical Medicine, Fajara, Gambia.
Julia StrandmarkVaccines and Immunity Theme, Medical Research Council Unit the Gambia at London School of Hygiene and Tropical Medicine, Fajara, Gambia.
Rym Ben-OthmanDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Oludare A OdumadePrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Kerry McEnaneyPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Nelly AmenyogbeWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia.
William S PomatPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Simon van HarenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Guzmán Sanchez-SchmitzPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Ryan R BrinkmanBC Cancer Agency, Vancouver, BC, Canada.
Hanno SteenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Robert E W HancockDepartment of Microbiology & Immunology, University of British Columbia, Vancouver, BC, Canada.
Scott J TebbuttPROOF Centre of Excellence, Vancouver, BC, Canada.
Peter C RichmondWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia.
Anita H J van den BiggelaarWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia.
Tobias R KollmannWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia.
Ofer LevyPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Al OzonoffPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Beate KampmannVaccines and Immunity Theme, Medical Research Council Unit the Gambia at London School of Hygiene and Tropical Medicine, Fajara, Gambia.
Boston Children's Hospital · USMRC Unit the Gambia · GMHarvard University · USThe University of Western Australia · AUBC Cancer Agency · CABC Children's Hospital · CAPapua New Guinea Institute of Medical Research · PGPrevention of Organ Failure · CAThe Kids Research Institute Australia · AUUniversity of British Columbia · CAUniversity of British Columbia Hospital · CA
Funding
Transcriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI OZONOFF, AL · 2017 to 2021
$24.7MNIAID NIH HHS U19 AI118608
Abstract
PubMed holds no abstract for this paper.
Indexed as
immunogenicitymarkersnewbornOMICSsystems biologyvaccine
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What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.