ArticleToxicology reports2020
Organochlorine pesticide levels in Greek patients with Parkinson's disease.
Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- A PLAN to address the Parkinson pandemic.Journal of Parkinson's disease · 2025Review
- Relationship between endocrine disruptors and neurodegenerative diseases: Systematic review and meta-analysis.iScience · 2025Article
- Multigenerational exposure to trace concentrations of DDT residues in Wistar rats: Effects on biometric development and biochemical parameters.Toxicology reports · 2025Article
- Neurotoxic Effects of Pesticides: Implications for Neurodegenerative and Neurobehavioral Disorders.Journal of xenobiotics · 2025Review
- Environmental Risk Factors for Parkinson's Disease: A Critical Review and Policy Implications.Movement disorders : official journal of the Movement Disorder Society · 2025Review
- A systematic review of pesticide exposure, associated risks, and long-term human health impacts.Toxicology reports · 2024Review
- The role and mechanisms of microbes in dichlorodiphenyltrichloroethane (DDT) and its residues bioremediation.Biotechnology reports (Amsterdam, Netherlands) · 2024Review
- Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.Annals of neurology · 2024Review
- The Body, the Brain, the Environment, and Parkinson's Disease.Journal of Parkinson's disease · 2024Review
- Article
- Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases.International journal of molecular sciences · 2022Review
- Impact of Pesticides on Human Health in the Last Six Years in Brazil.International journal of environmental research and public health · 2022Review
- Preventing Parkinson's Disease: An Environmental Agenda.Journal of Parkinson's disease · 2022Review
- Article
- New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents.Archives of toxicology · 2021Article
- Article
- Neurological Sequela of Acute Pesticide Poisoning Among Adults in Central Taiwan.Frontiers in neurology · 2021Article
- Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function.Toxicology reports · 2021Article
- "Metal elements and pesticides as risk factors for Parkinson's disease - A review".Toxicology reports · 2021Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is a neurodegenerative disease, mostly presenting with characteristic motor symptoms. Organochlorines (OC) are a class of widely-used pesticides that have been included among the list of environmental factors incriminated in PD pathogenesis. However, most studies reporting this association are based on questionnaires, and few have reported exposure data.
aimTo examine the relationship between OC blood concentrations and PD risk.
methodsIn the present study, we studied the concentrations of 8 OC compounds (hexachlorobenzene, heptachlor, hepachlor epoxide, c-chlordane, a-chlordane, p,p'-DDE, DDD, DDT) in 104 Greek PD patients and 110 healthy controls.
resultsAll substances studied were present in at least one sample. The most frequently detected (above the level of quantification) pesticides were p,p'-DDE (n = 214, 100 % of both groups) and hexachlorobenzene, HCB (n = 189, cases 46.5 %, controls 53.5 %). Higher levels of DDE were detected among PD patients in comparison to controls by using logistic regression analysis to control for confounders [Odds Ratio, OR (95 % confidence interval, C.I.)]: 2.592,(1.29-5.21)], whilst lower levels of HCB were detect among PD patients [OR,95 %CI:0.176(0.09-0.35)].
conclusionsOur data suggest that exposure to specific OCs is related to the risk of PD. Further studies, using real exposure data, are needed in order to confirm and extend these findings.
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