ArticleJournal of intensive care2020
Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients treated by extracorporeal CPR: a prospective observational cohort study in Japan.
Article in Journal of intensive care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- No-Flow Duration and Outcomes After Cardiogenic Out-of-Hospital Cardiac Arrest in Older Adults.JAMA network open · 2026Observational
- Reevaluating basic life support termination criteria using post-arrival data in Japanese out-of-hospital cardiac arrest patients.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Prehospital Blood pH Testing and Survival in Non-Traumatic Out-of-Hospital Cardiac Arrest: Insights from a Thai EMS Unit.Open access emergency medicine : OAEM · 2026Article
- Outcomes and implications of patients included vs excluded for extracorporeal cardiopulmonary resuscitation after initial activation.Resuscitation plus · 2026Article
- Article
- Clinical Outcomes of Out-of-Hospital Cardiac Arrest with ROSC: Insights from a Specialized Referral Center in Vietnam.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025Article
- Differential Effects of Targeted Temperature Management on Sex-Dependent Outcomes After Experimental Asphyxial Cardiac Arrest.Therapeutic hypothermia and temperature management · 2024Article
- Factors associated with neurological outcomes in patients experiencing out-of-hospital cardiac arrest and severe acidaemia: retrospective analysis of a nation-wide registry.Resuscitation plus · 2024Article
- Optimal timing of ultra-early diffusion-weighted MRI in out-of-hospital cardiac arrest patients based on a retrospective multicenter cohort study.Scientific reports · 2024Article
- Article
- The relationship between the initial pH and neurological outcome in patients with out-of-hospital cardiac arrest is affected by the status of recovery of spontaneous circulation on hospital arrival.Heart and vessels · 2024Article
- Intra-arrest blood-based biomarkers for out-of-hospital cardiac arrest: A scoping review.Journal of the American College of Emergency Physicians open · 2024Article
- Prognostic value of arterial carbon dioxide tension during cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients receiving extracorporeal resuscitation.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Article
- Overview and future prospects of out-of-hospital cardiac arrest registries in Japan.Resuscitation plus · 2024Review
- Outcome assessment for out-of-hospital cardiac arrest patients in Singapore and Japan with initial shockable rhythm.Critical care (London, England) · 2023Observational
- Benefits, key protocol components, and considerations for successful implementation of extracorporeal cardiopulmonary resuscitation: a review of the recent literature.Clinical and experimental emergency medicine · 2023Article
- Association between stress hyperglycemia on admission and unfavorable neurological outcome in OHCA patients receiving ECPR.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Never Say Never: Successful Extracorporeal Cardiopulmonary Resuscitation (ECPR) Following A Prolonged Out-of-Hospital Cardiac Arrest Due to Spontaneous Coronary Artery Dissection.European journal of case reports in internal medicine · 2023Article
- Early platelet dysfunction in patients receiving extracorporeal membrane oxygenation is associated with mortality.Journal of thrombosis and thrombolysis · 2022Observational
- Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest.Scientific reports · 2021Observational
Corrections and comments
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Authors and funding
28 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to identify the association of pH value in blood gas assessment with neurological outcome among out-of-hospital cardiac arrest (OHCA) patients treated by extracorporeal cardiopulmonary resuscitation (ECPR).
methodsWe retrospectively analyzed the database of a multicenter prospective observational study on OHCA patients in Osaka prefecture, Japan (CRITICAL study), from July 1, 2012 to December 31, 2016. We included adult OHCA patients treated by ECPR. Patients with OHCA from external causes such as trauma were excluded. We conducted logistic regression analysis to identify the odds ratio (OR) and 95% confidence interval (CI) of the pH value for 1 month favorable neurological outcome adjusted for potential confounders including sex, age, witnessed by bystander, CPR by bystander, pre-hospital initial cardiac rhythm, and cardiac rhythm on hospital arrival.
resultsAmong the 9822 patients in the database, 260 patients were finally included in the analysis. The three groups were Tertile 1: pH ≥ 7.030, Tertile 2: pH 6.875-7.029, and Tertile 3: pH < 6.875. The adjusted OR of Tertiles 2 and 3 compared with Tertile 1 for 1 month favorable neurological outcome were 0.26 (95% CI 0.10-0.63) and 0.24 (95% CI 0.09-0.61), respectively.
conclusionsThis multi-institutional observational study showed that low pH value (< 7.03) before the implementation of ECPR was associated with 1 month unfavorable neurological outcome among OHCA patients treated with ECPR. It may be helpful to consider the candidate for ECPR.
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