Evidence map›Paper›PMID 32426105›Full record

ArticleCell & bioscience2020

Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma.

Juliann G Kiang, Joan T Smith, Georgetta Cannon, Marsha N Anderson, Connie Ho, Min Zhai, Wanchang Cui, Mang Xiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 45 citations in OpenAlex.

  1. Ghrelin Induces CluInternational journal of molecular sciences · 2026
    Article
  2. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Review
  5. [Effects and mechanism of retinoic acid on radiation-induced skin injury in mice].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025
    Article
  6. Article
  7. Research on the mechanisms of natural products in radiation protection.Frontiers in bioengineering and biotechnology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Juliann G Kiang1Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814 USA.ORCID 0000-0002-3904-2350
Joan T Smith1Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814 USA.
Georgetta Cannon1Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814 USA.
Marsha N Anderson1Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814 USA.
Connie Ho4Department of Biochemistry, University of California, Berkeley, CA 94720 USA.
Min Zhai1Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814 USA.
Wanchang Cui1Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814 USA.
Mang Xiao1Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814 USA.
Armed Forces Institute of Pathology · USUniformed Services University of the Health Sciences · USUniversity of California, Berkeley · US

Funding

NIAID NIH HHS Y01 AI005045
6 · The paper itself

Abstract

backgroundCompared to radiation injury alone (RI), radiation injury combined wound (CI) further enhances acute radiation syndrome and subsequently mortality. We previously reported that therapy with Ghrelin, the 28-amino-acid-peptide secreted from the stomach, significantly increased 30-day survival and mitigated hematopoietic death by enhancing and sustaining granulocyte-colony stimulating factor (G-CSF) and keratinocyte chemoattractant (KC) in the blood and bone marrow; increasing circulating white blood cell depletion; inhibiting splenocytopenia; and accelerating skin-wound healing on day 30 after CI. Herein, we aimed to study the efficacy of Ghrelin on intestinal injury at early time points after CI.

methodsB6D2F1/J female mice were exposed to

resultsGhrelin therapy mitigated CI-induced increases in IL-1β, IL-6, IL-17A, IL-18, KC, and TNF-α in serum but sustained G-CSF, KC and MIP-1α increases in ileum. Histological analysis of ileum on day 15 showed that Ghrelin treatment mitigated ileum injury by increasing villus height, crypt depth and counts, as well as decreasing villus width and mucosal injury score. Ghrelin therapy increased AKT activation and ERK activation; suppressed JNK activation and caspase-3 activation in ileum; and reduced NF-κB, iNOS, BAX and Bcl-2 in ileum. This therapy recovered the tight junction protein and mitigated bacterial translocation and lipopolysaccharides levels. The results suggest that the capacity of Ghrelin therapy to reduce CI-induced ileum injury is mediated by a balanced NF-κB-AKT-MAPK network that leads to homeostasis of pro-inflammatory and anti-inflammatory cytokines.

conclusionsOur novel results are the first to suggest that Ghrelin therapy effectively decreases intestinal injury after CI.

Indexed as

AKTApoptosisBacteriaBAXBcl-2CaspaseERKGhrelinGIiNOSIonizing radiationJNKMAPKNF-κBSkin woundTight junction

Identifiers

PMID32426105
PMCPMC7216502
OpenAlexW3026236672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.