Evidence map›Paper›PMID 32425833›Full record

ArticleFrontiers in psychiatry2020

Neural Correlates of Working Memory Deficits in Different Adult Outcomes of ADHD: An Event-Related Potential Study.

Xixi Zhao, Hui Li, Encong Wang, Xiangsheng Luo, Chuanliang Han, Qingjiu Cao, Lu Liu, Jin Chen, Changming Wang, Stuart J Johnstone and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Xixi ZhaoThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Hui LiDepartment of Child Psychiatry, Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.
Encong WangUnit of Psychological Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Xiangsheng LuoDepartment of Child Psychiatry, Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.
Chuanliang HanState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Qingjiu CaoDepartment of Child Psychiatry, Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.
Lu LiuDepartment of Child Psychiatry, Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.
Jin ChenDepartment of Child Psychiatry, Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.
Changming WangThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Stuart J JohnstoneSchool of Psychology, Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia.
Yufeng WangDepartment of Child Psychiatry, Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.
Li SunDepartment of Child Psychiatry, Peking University Sixth Hospital/Institute of Mental Health, Beijing, China.
Peking University Sixth Hospital · CNCapital Medical University · CNBeijing Anding Hospital · CNBeijing Normal University · CNPeking University · CNUniversity of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated working memory (WM) processing in a longitudinal sample of young adults with persistent and remittent childhood-onset ADHD to investigate the neural correlates of working memory with adult outcomes of ADHD.

methodsForty-seven young Chinese adults who had been diagnosed with ADHD during childhood underwent follow-up assessments for an average of 9 years. The ADHD sample consisted of 25 ADHD persisters (mean age =18.38 ± 0.5 years) and 22 remitters (mean age = 18.78 ± 1.10 years), who were compared with 25 sex ratio- and IQ-matched healthy adults (mean age = 19.60 ± 1.22 years) in a verbal n-back task.

resultsNo differences in behavioral measures were observed across the three groups. Compared with the healthy controls, the ADHD persisters and remitters had larger N1 amplitudes and smaller P2 amplitudes, while no significant differences between the persistence and remission groups were observed. The P3 amplitudes of the remission and control groups were higher than that of the persistence group, but there was no significant difference between the remitters and healthy controls.

conclusionThe P3 amplitudes reflecting postdecisional processing and/or WM updating were sensitive to ADHD remission, as they might improve concurrently with ADHD symptoms. These results indicate that the N1, P2, and P3 components of WM processing might be potential biomarkers for different ADHD outcomes.

Indexed as

attention deficit/hyperactivity disorder (ADHD)event-related potentials (ERPs)n-backP3remittersworking memory (WM)

Identifiers

PMID32425833
PMCPMC7206828
OpenAlexW3021006097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.