Evidence map›Paper›PMID 32425816›Full record

SynthesisFrontiers in psychiatry2020

Which Symptoms, Complaints and Complications of the Gastrointestinal Tract Occur in Patients With Eating Disorders? A Systematic Review and Quantitative Analysis.

Caroline Riedlinger, Greta Schmidt, Alisa Weiland, Andreas Stengel, Katrin Elisabeth Giel, Stephan Zipfel, Paul Enck, Isabelle Mack

Registry-linked trialOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07112014 (Development of Gastrointestinal Symptoms in Patients With Anorexia Nervosa and Bulimia Nervosa During Weight Rehabilitation Over Time, Depending on the Nutritional Strategy), which is not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07112014 recruitingnot on this mapstarted 2025, after this paper: background citation

Development of Gastrointestinal Symptoms in Patients With Anorexia Nervosa and Bulimia Nervosa During Weight Rehabilitation Over Time, Depending on the Nutritional Strategy

TypeobservationalSponsorUniversity Hospital TuebingenRan2025 to 2027Enrolled185ConditionsAnorexia Nervosa, Bulimia Nervosa
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Management of Constipation in Eating Disorders-A Scoping Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Article
  10. Article
  11. Article
  12. The current clinical approach to feeding and eating disorders aimed to increase personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Approach to anorexia nervosa and atypical anorexia nervosa in adolescents.Canadian family physician Medecin de famille canadien · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caroline RiedlingerDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Greta SchmidtDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Alisa WeilandDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Andreas StengelDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Katrin Elisabeth GielDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Stephan ZipfelDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Paul EnckDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Isabelle MackDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEating disorders (ED) such as anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED) are often accompanied by a variety of psychological and physical comorbidities. Gastrointestinal (GI) symptoms are a classical feature in most patients with ED. The heterogeneity of studies on this topic is high, making it difficult to have a clear overview. The aim of this systematic review is therefore to provide an overview of subjectively and objectively measured differences and changes in the GI tract in patients with EDs, along with the occurrence of GI complications.

methodsA systematic literature search was conducted in PubMed, Web of Science, and Google Scholar to find all relevant studies examining GI problems in AN, BN, and BED. Quantitative analyses were performed for objective GI physiology measures where applicable.

resultsThe review differentiated between ED types and also between studies that report GI outcomes of ED in (i) human studies with an ED diagnosis excluding case reports that provide an overview of GI problems in ED and (ii) case reports with an ED diagnosis describing rare GI complications in ED. GI symptoms and impaired gastric transit times were frequent features of EDs with specific differences found for the ED types. During the time course of treatment, GI symptoms changed and/or improved but not completely. GI complications extended the range of GI problems observed, including a variety of serious complications such as gastric dilatation.

conclusionsProblems of the GI tract are frequent in patients with ED and it is likely that they complicate therapy, especially in patients with AN. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration number: CRD42019100585.

Indexed as

binge eating disorder (BED)bulimia nervosaeating disorder (ED)gastrointestinal complaintgastrointestinal complicationgastrointestinal symptomsystematic review

Identifiers

PMID32425816
PMCPMC7212454
OpenAlexW3016831363

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.