Evidence map›Paper›PMID 32425796›Full record

ArticleFrontiers in pharmacology2020

Apolipoprotein A-I Mimetic Peptide L-4F Suppresses Granulocytic-Myeloid-Derived Suppressor Cells in Mouse Pancreatic Cancer.

Meiyu Peng, Qi Zhang, Yanqing Liu, Xiangdong Guo, Jiyu Ju, Lingzhi Xu, Yuanyuan Gao, Daquan Chen, Dongzhen Mu, Rongxin Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Translational cancer research · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Apolipoproteins: New players in cancers.Frontiers in pharmacology · 2022
    Review
  10. Article
  11. Review
  12. Apolipoprotein mimetics in cancer.Seminars in cancer biology · 2021
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Meiyu PengDepartment of Immunology, School of Basic Medical Sciences, Weifang Medical University, Weifang, China.
Qi ZhangTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, China.
Yanqing LiuDepartment of Breast Surgery, Yantai Yuhuangding Hospital, Yantai, China.
Xiangdong GuoLaboratory of Immunology and Inflammation, Department of Immunology, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Medical University, Tianjin, China.
Jiyu JuDepartment of Immunology, School of Basic Medical Sciences, Weifang Medical University, Weifang, China.
Lingzhi XuDepartment of Immunology, School of Basic Medical Sciences, Weifang Medical University, Weifang, China.
Yuanyuan GaoDepartment of Pharmaceutics, School of Pharmacy, Weifang Medical University, Weifang, China.
Daquan ChenSchool of Pharmacy, Yantai University, Yantai, China.
Dongzhen MuDepartment of Immunology, School of Basic Medical Sciences, Weifang Medical University, Weifang, China.
Rongxin ZhangGuangdong Province Key Laboratory for Biotechnology Drug Candidates, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China.
Weifang Medical University · CNTianjin Medical University · CNGuangdong Pharmaceutical University · CNYantai University · CNYuhuangding Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-4F is an apolipoprotein A-I (ApoA-I) mimetic peptide, it was engineered to imitate the anti-inflammatory and anti-oxidative activity of ApoA-I. In this paper, H7 cell was used to construct a mouse model of pancreatic cancer in situ, and the mice were treated with L-4F. Then, the development of pancreatic cancer and myeloid-derived suppressor cells (MDSCs) infiltration were investigated

Indexed as

anti-tumorL-4Fpancreatic cancerPMN-MDSCsSTAT3

Identifiers

PMID32425796
PMCPMC7204910
OpenAlexW3023461529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.