ArticleDose-response : a publication of International Hormesis Society
Radiation Exposure Associated With Computed Tomography in Childhood and the Subsequent Risk of Cancer: A Meta-Analysis of Cohort Studies.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.Cancer epidemiology · 2024Pooled it
- Pooled it
- Clinical Assessment of Obesity Beyond Body Mass Index: Adiposity Evaluation, Body-Composition Phenotyping and Disease Staging: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Feasibility study of the FRACTURE sequence in evaluating pediatric skull base bone lesions.European radiology · 2026Article
- Pediatric Trauma in the Emergency Department: Clinical Risk Stratification, CT Utilization and Radiation Burden in a Tertiary Care Cohort.Journal of clinical medicine · 2026Article
- Clinical Impact of Ultrafast Cranial MRI Implementation in Children Under Six Years of Age.Journal of clinical medicine · 2026Article
- Retrospective analysis of the clinical features and prognosis of idiopathic pulmonary fibrosis combined with lung cancer.BMC cancer · 2025Article
- Medical Imaging and Pediatric and Adolescent Hematologic Cancer Risk.The New England journal of medicine · 2025Article
- Upper Limb-Salvage Surgery in Pediatric Patients with Malignant Bone Tumors Using Microsurgical Free Flaps: Long-Term Follow-Up.Biomedicines · 2025Article
- Impact of deep learning reconstruction on radiation dose reduction and cancer risk in CT examinations: a real-world clinical analysis.European radiology · 2025Article
- Computed Tomography Findings of Children Under 3 Years of Age with Mild Traumatic Brain Injury (TBI) and No Neurological Focal Signs.Journal of clinical medicine · 2025Article
- Interfractional body surface monitoring using daily cone-beam computed tomography imaging for pediatric adaptive proton therapy.Physics and imaging in radiation oncology · 2025Article
- Craniofacial Imaging of Pediatric Patients by Ultrashort Echo-Time Bone-Selective MRI in Comparison to CT.Academic radiology · 2024Article
- Optimal image quality and radiation doses with optimal tube voltages/currents for pediatric anthropomorphic phantom brains.PloS one · 2024Article
- Article
- Optimal timing of a γH2AX analysis to predict cellular lethal damage in cultured tumor cell lines after exposure to diagnostic and therapeutic radiation doses.Journal of radiation research · 2023Article
- Active learning-based multistage sequential decision-making model with application on common bile duct stone evaluation.Journal of applied statistics · 2023Article
- Magnetic Resonance Imaging Versus Computed Tomography for Three-Dimensional Bone Imaging of Musculoskeletal Pathologies: A Review.Journal of magnetic resonance imaging : JMRI · 2022Review
- Low-Cost Probabilistic 3D Denoising with Applications for Ultra-Low-Radiation Computed Tomography.Journal of imaging · 2022Article
- Radiation dose reduction for chest radiography of infants in intensive care units using a high peak kilovoltage-technique.Pediatric radiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComputed tomography (CT) is used worldwide; however, recent studies suggest that CT radiation exposure during childhood may be a risk factor for cancer, although the data are inconsistent.
methodsA comprehensive search of electronic databases including PubMed, SpringerLink, Embase, Cochrane Library, Elsevier/ScienceDirect, Medline, Orbis, and Web of Science databases from January 1990 to November 2018 for observational epidemiologic studies reporting associations between radiation exposure from CT in childhood and the subsequent risk of cancer was conducted. A linear model was used to explore the dose-response relationship.
resultsSeven studies with 1180 987 children enrolled were included. The risk of later cancer was 1.32-fold higher for children exposed to CT than those without exposure. Compared to those not exposed to pediatric CT, the relative risk (RRs) were larger for the higher doses but with wider CIs (RR for 5-10 mGy: 0.90, 95% CI: 0.69-1.12; RR for 10-15 mGy: 1.02, 95% CI: 0.86-1.18; RR for >15 mGy: 1.13, 95% CI: 0.97-1.30), the leukemia risk was higher in exposed children (RR: 1.23, 95% CI: 1.10-1.36), and brain cancer risk was higher in exposed children (RR: 1.54, 95% CI: 0.84-2.45).
conclusionsOur analysis suggested that radiation exposure from CT during childhood is associated with a subsequently elevated risk of cancer. However, caution is needed when interpreting these results because of the heterogeneity among the studies. The findings should be confirmed in further studies with longer follow-up periods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.