Evidence map›Paper›PMID 32425424›Full record

ArticleJournal of orthopaedics

Does osteoporosis affect the healing of subcapital humerus and distal radius fractures?

E A Gorter, B M Gerretsen, P Krijnen, N M Appelman-Dijkstra, I B Schipper

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Clinical outcome of periprosthetic femoral fractures: the influence of fracture pattern and patient specific risk factors.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
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  6. Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

E A GorterLeiden University Medical Center, Departments of Trauma Surgery, Center for Bone Quality, Leiden, P.O. Box 9600, 2300, RC, Leiden, the Netherlands.
B M GerretsenLeiden University Medical Center, Departments of Trauma Surgery, Center for Bone Quality, Leiden, P.O. Box 9600, 2300, RC, Leiden, the Netherlands.
P KrijnenLeiden University Medical Center, Departments of Trauma Surgery, Center for Bone Quality, Leiden, P.O. Box 9600, 2300, RC, Leiden, the Netherlands.
N M Appelman-DijkstraLeiden University Medical Center, Departments of Internal Medicine, Center for Bone Quality, Leiden, P.O. Box 9600, 2300, RC, Leiden, the Netherlands.
I B SchipperLeiden University Medical Center, Departments of Trauma Surgery, Center for Bone Quality, Leiden, P.O. Box 9600, 2300, RC, Leiden, the Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAnimal models indicate that osteoporosis may negatively influence the fracture healing process, but clinical studies on this topic are scarce. In this study we investigated the effect of osteoporosis on fracture healing in patients with an upper extremity fracture.

methodsThis retrospective cohort study included all patients aged 50 years or older, with a fracture of the proximal humerus or the distal radius treated in the period June 2012 to July 2015 and a DEXA scan within a year after fracture. The incidence of delayed-union and non-union were compared between patients with or without osteoporosis (BMD T score ≤ -2.5SD). A secondary analysis was performed with a more pragmatically definition; BMD T score ≤ -2.5SD or a proximal humerus fracture with a T-score between -2.5SD and -1.0SD.

resultsOsteoporosis was diagnosed in 133/455 patients (29.2%). A total of 461 fractures (distal radius n = 311 and proximal humerus n = 150) were treated. Radiological delayed- or non-union was described in 11/461 cases (2.4%); all proximal humerus fractures of which 6 cases (1.3%) were clinically manifest. The incidence of delayed- or non-union in fracture treatment did not differ between patients with osteoporosis (5/137 fractures) and the patients without osteoporosis (6/324 fractures) (p = 0.27). In the second analysis a significantly higher incidence was found in patients with osteoporosis (10/214 fractures vs 1/247 fractures p = 0.003).

conclusionsThe results of this study suggest that osteoporosis does not significantly influence the progress of fracture healing in distal radius and proximal humerus fractures, although there seems to be a tendency towards a negative effect.

Indexed as

Delayed unionFractureFracture healingNon-unionOsteoporosis

Identifiers

PMID32425424
PMCPMC7226641
OpenAlexW3021798889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.