Evidence map›Paper›PMID 32425260›Full record

ArticleSeminars in arthritis and rheumatism2020

Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs.

Xabier Michelena, Helena Borrell, Mireia López-Corbeto, María López-Lasanta, Estefanía Moreno, María Pascual-Pastor, Alba Erra, Mayte Serrat, Esther Espartal, Susana Antón and 10 more

Open access · greenAbstract read
In one paragraph

Article in Seminars in arthritis and rheumatism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 8 pooled it
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 8 syntheses or guidelines pooled it, 151 citations in OpenAlex.

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  14. The role of regulatory T cells in vitiligo and therapeutic advances: a mini-review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Review
  15. Article
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  19. The Impact of the COVID-19 Pandemic on Inflammatory Rheumatic Diseases.Journal of clinical practice and research · 2023
    Article
  20. COVID-19 in immunocompromised children and adolescents.Clinical and experimental pediatrics · 2023
    Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 2 countries.

Xabier MichelenaRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK. Electronic address: medxm@leeds.ac.uk.
Helena BorrellRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: hborrell@vhebron.net.
Mireia López-CorbetoRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: mireia.lopez@vhir.org.
María López-LasantaRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: maria.alopez@vhir.org.
Estefanía MorenoRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: emoreno@vhebron.net.
María Pascual-PastorRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: maria.pascual@vhebron.net.
Alba ErraRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: maerra@vhebron.net.
Mayte SerratRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: mserrat@vhebron.net.
Esther EspartalRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: eespartal@vhebron.net.
Susana AntónRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: santon@vhebron.net.
Gustavo Adolfo AñezRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: gustavo.anez@vhir.org.
Raquel Caparrós-RuizRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: rcaparros@vhebron.net.
Andrea PlumaRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: apluma@vhebron.net.
Ernesto Trallero-AraguásRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: etrallero@vhebron.net.
Mireia Barceló-BruRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: mbarcelo@vhebron.net.
Miriam AlmirallRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: malmirall@vhebron.net.
Juan José De AgustínRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: jjagor@hotmail.com.
Jordi LladósRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: jordi.llados@vhir.org.
Antonio JuliàRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: toni.julia@vhir.org.
Sara MarsalRheumatology Department, Rheumatology Research Group, Vall d'Hebron Research Institute, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: sara.marsal@vhir.org.
Vall d'Hebron Institut de Recerca · ESUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To investigate the incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases receiving targeted biologic and synthetic disease modifying anti-rheumatic drugs (tDMARDs) and to explore the possible effect of these treatments in the clinical expression of COVID-19. Methods: A cross-sectional study comprising of a telephone survey and electronic health records review was performed including all adult and paediatric patients with rheumatic diseases treated with tDMARDs in a large rheumatology tertiary centre in Barcelona, Spain. Demographics, disease activity, COVID-19 related symptoms and contact history data were obtained from the start of the 2020 pandemic. Cumulative incidence of confirmed cases (SARS-CoV-2 positive PCR test) was compared to the population estimates for the same city districts from a governmental COVID-19 health database. Suspected cases were defined following WHO criteria and compared to those without compatible symptoms. Results: 959 patients with rheumatic diseases treated with tDMARDs were included. We identified 11 confirmed SARS-CoV-2 positive cases in the adult cohort and no confirmed positive cases in the paediatric cohort. COVID-19 incidence rates of the rheumatic patient cohort were very similar to that of the general population [(0.48% (95% CI 0.09 to 0.87%)] and [0.58% (95% CI 0.56 to 0.60%)], respectively. We found significant differences in tDMARDs proportions between the suspected and non-suspected cases ( Conclusion: Adult and paediatric patients with rheumatic diseases on tDMARDs do not seem to present a higher risk of COVID-19 or a more severe disease outcome when compared to general population.

Indexed as

AdolescentAdultAgedAntirheumatic AgentsBetacoronavirusBiological ProductsCase-Control StudiesChildChild, PreschoolCoronavirus InfectionsCOVID-19Cross-Sectional StudiesFemaleHumansIncidenceInfantAntirheumatic AgentsBiological ProductsCOVID-19EpidemiologyPediatric rheumatologyRheumatic diseasesTargeted disease modifying anti-rheumatic drugs

Identifiers

PMID32425260
PMCPMC7229730
OpenAlexW3025283885

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.