Evidence map›Paper›PMID 32425246›Full record

ReviewPsychosomatics

Psychopharmacology of COVID-19.

Melanie Bilbul, Patricia Paparone, Anna M Kim, Shruti Mutalik, Carrie L Ernst

Open access · greenAbstract readReview
In one paragraph

Review in Psychosomatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Melanie BilbulDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
Patricia PaparoneDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
Anna M KimDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
Shruti MutalikDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
Carrie L ErnstDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: carrie.ernst@mssm.edu.
Icahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: With the rapid, global spread of severe acute respiratory syndrome coronavirus 2, hospitals have become inundated with patients suffering from coronavirus disease 2019. Consultation-liaison psychiatrists are actively involved in managing these patients and should familiarize themselves with how the virus and its proposed treatments can affect psychotropic management. The only Food and Drug Administration-approved drug to treat COVID-19 is remdesivir, and other off-label medications used include chloroquine and hydroxychloroquine, tocilizumab, lopinavir/ritonavir, favipiravir, convalescent plasma therapy, azithromycin, vitamin C, corticosteroids, interferon, and colchicine. Objective: To provide an overview of the major safety considerations relevant to clinicians who prescribe psychotropics to patients with COVID-19, both related to the illness and its proposed treatments. Methods: In this targeted review, we performed structured literature searches in PubMed to identify articles describing the impacts of COVID-19 on different organ systems, the neuropsychiatric adverse effects of treatments, and any potential drug interactions with psychotropics. The articles most relevant to this one were included. Results: COVID-19 impacts multiple organ systems, including gastrointestinal, renal, cardiovascular, pulmonary, immunological, and hematological systems. This may lead to pharmacokinetic changes that impact psychotropic medications and increase sensitivity to psychotropic-related adverse effects. In addition, several proposed treatments for COVID-19 have neuropsychiatric effects and potential interactions with commonly used psychotropics. Conclusions: Clinicians should be aware of the need to adjust existing psychotropics or avoid using certain medications in some patients with COVID-19. They should also be familiar with neuropsychiatric effects of medications being used to treat this disease. Further research is needed to identify strategies to manage psychiatric issues in this population.

Indexed as

Adenosine MonophosphateAdrenal Cortex HormonesAlanineAmidesAntibodies, Monoclonal, HumanizedAnti-Inflammatory AgentsAntiviral AgentsAscorbic AcidAzithromycinBetacoronavirusChloroquineColchicineCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentCOVID-19 SerotherapyAdenosine MonophosphateAdrenal Cortex HormonesAlanineAmidesAntibodies, Monoclonal, HumanizedAnti-Inflammatory AgentsAntiviral AgentsAscorbic AcidAzithromycinChloroquineColchicineDrug CombinationsfavipiravirHydroxychloroquineInterferonsLopinavirlopinavir-ritonavir drug combinationPsychotropic DrugsPyrazinesremdesivirRitonavirtocilizumabVitaminsCOVID-19psychopharmacologypsychotropicside effects

Identifiers

PMID32425246
PMCPMC7232075
OpenAlexW3024773320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.