ArticleeLife2020
Acetylcholine acts on songbird premotor circuitry to invigorate vocal output.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Cholinergic signaling differentially regulates a vocal motor pallial nucleus to stabilize adult birdsong.Communications biology · 2026Article
- Modeling Emotional Arousal With Turbulence Measured by EEG.Psychophysiology · 2025Article
- Perineuronal nets in motor circuitry regulate the performance of learned vocalizations in songbirds.Communications biology · 2025Article
- Social context affects sequence modification learning in birdsong.Frontiers in psychology · 2025Article
- Transcriptomic Correlates of State Modulation in GABAergic Interneurons: A Cross-Species Analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Knowns and unknowns about the neurobiology of stuttering.PLoS biology · 2024Article
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- Distinct patterns of gene expression in the medial preoptic area are related to gregarious singing behavior in European starlings (Sturnus vulgaris).BMC neuroscience · 2023Article
- Analogies of human speech and bird song: From vocal learning behavior to its neural basis.Frontiers in psychology · 2023Review
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- Arousal elevation drives the development of oscillatory vocal output.Journal of neurophysiology · 2022Article
- Complementary roles of serotonergic and cholinergic systems in decisions about when to act.Current biology : CB · 2022Article
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- Article
- Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits.Science (New York, N.Y.) · 2021Article
- Acetylcholine in action.eLife · 2020Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Acetylcholine is well-understood to enhance cortical sensory responses and perceptual sensitivity in aroused or attentive states. Yet little is known about cholinergic influences on motor cortical regions. Here we use the quantifiable nature of birdsong to investigate how acetylcholine modulates the cortical (pallial) premotor nucleus HVC and shapes vocal output. We found that dialyzing the cholinergic agonist carbachol into HVC increased the pitch, amplitude, tempo and stereotypy of song, similar to the natural invigoration of song that occurs when males direct their songs to females. These carbachol-induced effects were associated with increased neural activity in HVC and occurred independently of basal ganglia circuitry. Moreover, we discovered that the normal invigoration of female-directed song was also accompanied by increased HVC activity and was attenuated by blocking muscarinic acetylcholine receptors. These results indicate that, analogous to its influence on sensory systems, acetylcholine can act directly on cortical premotor circuitry to adaptively shape behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.