Evidence map›Paper›PMID 32424995›Full record

ArticleEMBO reports2020

ZSCAN4

Annaelena Troiano, Consiglia Pacelli, Vitalba Ruggieri, Rosella Scrima, Martina Addeo, Francesca Agriesti, Valeria Lucci, Gina Cavaliere, Maria Pina Mollica, Marianna Caterino and 10 more

Abstract read
In one paragraph

Article in EMBO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Identification ofGenes · 2022
    Article
  7. Review
  8. ZSCAN4EMBO reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Annaelena Troiano *Department of Biology, University of Naples Federico II, Naples, Italy.
Consiglia Pacelli *Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID 0000-0003-4915-5823
Vitalba RuggieriLaboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
Rosella ScrimaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Martina AddeoDepartment of Biology, University of Naples Federico II, Naples, Italy.
Francesca AgriestiLaboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
Valeria LucciDepartment of Biology, University of Naples Federico II, Naples, Italy.
Gina CavaliereDepartment of Biology, University of Naples Federico II, Naples, Italy.
Maria Pina MollicaDepartment of Biology, University of Naples Federico II, Naples, Italy.
Marianna CaterinoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.
Margherita RuoppoloDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.
Simona PaladinoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.ORCID 0000-0001-5332-6774
Daniela SarnataroDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.ORCID 0000-0002-6094-8384
Feliciano VisconteCEINGE Biotecnologie Avanzate s.c.a.r.l., Napoli, Italy.
Francesco TucciDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID 0000-0001-6247-5392
Piervito LoprioreDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID 0000-0002-9789-3129
Viola CalabròDepartment of Biology, University of Naples Federico II, Naples, Italy.
Nazzareno CapitanioDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Claudia Piccoli *Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID 0000-0001-9739-4680
Geppino Falco *Department of Biology, University of Naples Federico II, Naples, Italy.ORCID 0000-0001-6193-7233

Funding

Consiglio Nazionale delle Ricerche (CNR) Interomics2017Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) 2017XJ38A4Università degli Studi di Napoli Federico II (UNINA) STAR Linea 1- 2014
6 · The paper itself

Abstract

Cultured mouse embryonic stem cells are a heterogeneous population with diverse differentiation potential. In particular, the subpopulation marked by Zscan4 expression has high stem cell potency and shares with 2 cell stage preimplantation embryos both genetic and epigenetic mechanisms that orchestrate zygotic genome activation. Although embryonic de novo genome activation is known to rely on metabolites, a more extensive metabolic characterization is missing. Here we analyze the Zscan4

Indexed as

Mouse Embryonic Stem CellsTranscription FactorsAnimalsBlastocystMetabolomeMiceOxidative StressTranscription Factorscell intermediate metastateembryonic stem cellsheterogeneitymetabolismpluripotency

Identifiers

PMID32424995
PMCPMC7271321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.