ArticleBrain and behavior2020
The μ-opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The Mental Roots of Performance: A Preliminary Meta-Analysis of Cognitive Genes and Athlete Status.Molecular neurobiology · 2025Pooled it
- Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature.European child & adolescent psychiatry · 2023Pooled it
- Disordered eating in early childhood: DRD2 and COMT gene polymorphisms and behavioral features in family trios.Eating and weight disorders : EWD · 2026Article
- The impact of childhood maltreatment and parental styles on telomere length: the modulatory role of A118G.European journal of psychotraumatology · 2025Article
- Early Screen Exposure and Preadolescent Outcomes: A Longitudinal Follow-Up on Dysregulation, Academic Achievements, and Capacity to Be Alone.Children (Basel, Switzerland) · 2025Article
- Psychopathological Risk During Adolescent Study-Abroad: A Larger-Cohort Update of a Previous Longitudinal Study.European journal of investigation in health, psychology and education · 2025Article
- Recent Developments in Eating Disorders in Children: A Comprehensive Perspective.Journal of clinical medicine · 2025Article
- Body dissatisfaction, drive for thinness, and psychopathological symptoms in preadolescents who use Instagram.Eating and weight disorders : EWD · 2025Article
- Integrating Screens and Spoons: An Exploratory Study on Digital Technology's Influence on Parent-Child Interactions.European journal of investigation in health, psychology and education · 2025Article
- Fathers' Cocaine Use and Parent-Child Feeding Interactions.Journal of clinical medicine · 2025Article
- Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review.Frontiers in public health · 2025Review
- Fathers as Key Figures Shaping the Foundations of Early Childhood Development: An Exploratory Longitudinal Study on Web-Based Intervention.Journal of clinical medicine · 2024Article
- Factor Structure of the Experiences in Close Relationships-Relationship Structures Scale (ECR-RS) in Siblings of Children with Chronic Disorders.Children (Basel, Switzerland) · 2024Article
- Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment.Translational psychiatry · 2024Article
- Stability of and Change in Psychopathological Risk Levels in Pre-Early Adolescents before, during, and after Their Study Sojourns: A Descriptive Study.European journal of investigation in health, psychology and education · 2024Article
- Anxious-depressive attack and rejection sensitivity-Toward a new approach to treatment-resistant depression.Neuropsychopharmacology reports · 2024Review
- Autonomic response and attachment style in disruptive mood dysregulation disorder.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- Solving the Global Opioid Crisis: Incorporating Genetic Addiction Risk Assessment with Personalized Dopaminergic Homeostatic Therapy and Awareness Integration Therapy.Journal of addiction psychiatry · 2024Article
- Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse.Frontiers in neuroanatomy · 2024Review
- Epidemiology, Etiology and Intervention Strategies for Peri-Partum Depression in Mothers.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe A118G single nucleotide polymorphism (SNP) of the μ-opioid receptor gene, with high expression of the A allele and low expression of the G allele, has been associated with emotional/behavioral dysregulation and depressive disorders and is recognized as a mediator of affiliative behavior. No study has thus far investigated this SNP in school-age children with disruptive mood regulation disorder (DMDD). This study compared a sample of healthy children and their mothers with a sample of children with DMDD and their mothers, evaluating whether insecure attachment and psychopathological symptoms are associated with A allele- or G allele-carrying mothers and children and whether caregiving capacities are associated with A allele- or G allele-carrying mothers.
methodsFor evaluation of their psychopathological symptoms and attachment styles, mothers filled out the CBCL/6-18, the SCL-90-R, and the ECR. To evaluate the types of relationship children were experiencing with their mothers, children filled out the ECR-revised child version and the PBI. Genotypic analyses were conducted on DNA samples obtained by buccal swabbing from children and mothers.
resultsAn insecure attachment style was more frequent in mothers and children carrying the G allele (G/G + A/G genotypes). In the clinical sample, G allele-carrying children scored higher than homozygous A/A ones on the subscales of Withdrawal and Conduct Problems. G-carrying mothers showed higher interpersonal sensitivity, depression, hostility, and paranoid ideation and provided less care than A/A mothers.
conclusionsThis study offers new insights into the associations between the A118G SNP of the μ-opioid receptor gene and emotional/behavioral functioning, attachment style in children, and psychopathology and caregiving ability in mothers.
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