Evidence map›Paper›PMID 32424803›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2020

Genetic polymorphisms and haplotypes of BRCA1 gene associated with quality of life and survival among patients with non-small-cell lung cancer.

Tong Su, Hao Sun, Xiaofang Lu, Chen He, Lei Xiao, Jingwen He, Yang Yang, Yunxiang Tang

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

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6citing papers in PubMed, 1 pooled it
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3 · Its place in the literature

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6 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  4. Perturbations in inflammatory pathways are associated with shortness of breath profiles in oncology patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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5 · Who and what money

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8 authors.

Tong SuCollege of Psychology, Navy Medical University, 800 Xiangyin Rd., Shanghai, 200433, China.
Hao SunDepartment of Neurology, The General Hospital of Western Theater Command, Chengdu, China.
Xiaofang LuDepartment of Laboratory Medicine, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China.
Chen HeCollege of Psychology, Navy Medical University, 800 Xiangyin Rd., Shanghai, 200433, China.
Lei XiaoCollege of Psychology, Navy Medical University, 800 Xiangyin Rd., Shanghai, 200433, China.
Jingwen HeCollege of Psychology, Navy Medical University, 800 Xiangyin Rd., Shanghai, 200433, China.
Yang YangDepartment of Psychology, University of Louisiana at Lafayette, 104 E. University Circle, Lafayette, LA, 70504, USA. yangyang.psi@gmail.com.
Yunxiang TangCollege of Psychology, Navy Medical University, 800 Xiangyin Rd., Shanghai, 200433, China. tangyun7633@sina.com.

Funding

National Science Foundation of China 81602734
6 · The paper itself

Abstract

purposeQuality of life (QoL) and prognosis of lung cancer (LC) patients are poor. Previous studies focused less on the relationship between genetic factors and the QoL of LC patients. The current study is intended to explore the association of SNPs and haplotypes of BRCA1 and the QoL and survival of patients with LC.

methodsQOL of 291 non-small-cell LC patients was measured by EORTC Core Quality of Life Questionnaire (QLQ-C30) and EORTC Quality of Life Questionnaire-Lung Cancer 13 (QLQ-LC13) before discharge. Three tag SNPs of the BRCA1 gene (rs1799966, rs3737559, rs8067269) were detected using an improved multiplex ligation detection reaction (iMLDR) technique. Haplotype analysis was conducted using the software Haploview 4.2. The patients' survival was followed up every six months until March 2019.

resultsrs8067269 was associated with physical functioning (β = 7.97, p = 0.024) and diarrhea (Odds ratios (OR) 0.32, p = 0.042). rs1799966-rs3737559-rs8067269 haplotype was associated with several domains of QoL, including physical functioning (TCG vs. CCA: β = 6.21, p = 0.010), worse dyspnea (TCG vs. CTA: OR 2.05, p = 0.031) and peripheral neuropathy (TCG vs. CTA: OR 3.91, p = 0.030). BRCA1 rs1799966 CC genotype, rs8067269 AA genotype and CCA haplotype were associated with longer survival time of LC patients (p < 0.05).

conclusionSNPs and haplotypes of BRCA1 gene were associated with the QoL and survival of patients with LC. Patients with certain genotypes and haplotypes (i.e., rs8067269 AA genotype, or CCA haplotype) had better QoL and prognosis.

Indexed as

AdultAgedAged, 80 and overBRCA1 ProteinCarcinoma, Non-Small-Cell LungFemaleGenes, BRCA1HaplotypesHumansLung NeoplasmsMaleMiddle AgedPolymorphism, GeneticPolymorphism, Single NucleotidePrognosisQuality of LifeBRCA1 ProteinBRCA1 protein, humanBRCA1 geneHaplotypeNon-small-cell lung cancerPolymorphismQuality of lifeSurvival

Identifiers

PMID32424803

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