SynthesisEuropean journal of pediatrics2020
SARS-COV-2 infection in children and newborns: a systematic review.
Synthesis in European journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 262 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
262 citing papers in PubMed, 9 syntheses or guidelines pooled it, 554 citations in OpenAlex.
- A systematic review on impact of SARS-CoV-2 infection.Microbiological research · 2023Pooled it
- Mother-to-child transmission of SARS-CoV-2 infection in high-income countries: a systematic review and meta-analysis of prospective observational studies.Scientific reports · 2023Pooled it
- Mechanisms of pediatric ischemic strokes in COVID-19: a systematic review.Frontiers in stroke · 2023Pooled it
- COVID-19 in Neonates with Positive RT-PCR Test. Systematic Review.Archives of medical research · 2022Pooled it
- Prevalence of Coronavirus Disease 2019 (COVID-19) in Different Clinical Stages before the National COVID-19 Vaccination Programme in Malaysia: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Pediatric neurosurgery AC-after COVID-19: What has really changed? A review of the literature.Frontiers in pediatrics · 2022Pooled it
- Do we need to vaccinate every child against COVID-19: What evidence suggests-A systematic review of opinions.Frontiers in public health · 2022Pooled it
- Diagnostic Imaging in Newborns, Children and Adolescents Infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Is There a Realistic Alternative to Lung High-Resolution Computed Tomography (HRCT) and Chest X-Rays? A Systematic Review of the Literature.Ultrasound in medicine & biology · 2021Pooled it
- Radiological Findings of COVID-19 in Children: A Systematic Review and Meta-Analysis.Journal of tropical pediatrics · 2021Pooled it
- SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study.The Lancet. Child & adolescent health · 2021Trial
- Risk Factors of COVID-19 Severity and Related Death in Children in the Post-Pandemic Era.Microorganisms · 2026Article
- Survival analysis and mortality predictors of COVID-19 in Moroccan children: A multicenter study.IJID regions · 2026Article
- Trimester of maternal SARS-CoV-2 infection differentially predicts newborn size in the COVID-19 Mother Baby Outcomes (COMBO) cohort.Pediatric research · 2026Article
- Pulmonary Function and Associated Prognostic Factors in Children After COVID-19: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Observational
- From Fear to Vaccination: Changing Needs of Congenital Heart Defect Patients and Relatives over the Course of the COVID-19 Pandemic.Journal of clinical medicine · 2025Article
- Do timing and severity of gestational COVID-19 impact perinatal and neonatal outcomes?Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Paxlovid for the treatment of severe or critical COVID-19 in children.BMC pediatrics · 2025Article
- Histopathological examination of lung from infant with lethal COVID-19 with special attention on pneumocytes type II and the immune infiltrate: a case study.Italian journal of pediatrics · 2025Article
- Impact of COVID-19 on paediatric care in Japan: Analysis of national health insurance claims data.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Remdesivir Use in Pediatric Patients with Acute SARS-CoV-2 Infection Is Safe and Well Tolerated.Children (Basel, Switzerland) · 2025Article
202 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent outbreak of a novel Coronavirus responsible for a Severe Acute Respiratory Syndrome (SARS-CoV-2) is spreading globally. The aim of this study was to systematically review main clinical characteristics and outcomes of SARS-CoV-2 infections in pediatric age. An electronic search was conducted in PubMed database. Papers published between 1 January and 1 May 2020 including children aged 0-18 years were selected. Sixty-two studies and three reviews were included, with a total sample size of 7480 children (2428/4660 males, 52.1%; weighted mean age 7.6 years). Patients showed mainly mild (608/1432, 42.5%) and moderate (567/1432, 39.6%) signs of the infection. About 2% of children were admitted to the pediatric intensive care unit. The most commonly described symptoms were fever (51.6%) and cough (47.3%). Laboratory findings were often unremarkable. Children underwent a chest CT scan in 73.9% of all cases, and 32.7% resulted normal. Overall, the estimated mortality was 0.08%. A higher proportion of newborns was severely ill (12%) and dyspnea was the most common reported sign (40%).Conclusion: SARS-CoV-2 affects children less severely than adults. Laboratory and radiology findings are mainly nonspecific. Larger epidemiological and clinical cohort studies are needed to better understand possible implications of COVID-19 infection in children.What is Known:• A novel Coronavirus has been recently identified as responsible for a new Severe Acute Respiratory Syndrome (SARS-CoV-2) spreading globally.• There is limited evidence on SARS-CoV2 infection in children.What is New:• Systematically reviewed available evidence showed that children with SARS-CoV-2 infection may have a less severe pattern of disease in comparison to adults.• Blood tests and radiology findings are mainly nonspecific in children but may help to identify those who are severely ill.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.