Evidence map›Paper›PMID 32424728›Full record

ArticleHernia : the journal of hernias and abdominal wall surgery2020

Comprehensive analysis reveals a six-gene signature and associated drugs in mimic inguinal hernia model.

B Zhao, Z Wan, J Wang, H Liu, Y Zhou, W Chen, X Zhang, Y Wang, L Xiao, Y Zhao

Abstract read
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In one paragraph

Article in Hernia : the journal of hernias and abdominal wall surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Exploring serumHeliyon · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

B ZhaoDepartment of Oncology and Vascular Interventional Radiology, Zhongshan Hospital, Xiamen University, Xiamen, China.
Z WanDepartment of Oncology and Vascular Interventional Radiology, Zhongshan Hospital, Xiamen University, Xiamen, China.
J WangDepartment of Emergency, Zhongshan Hospital, Xiamen University, Xiamen, China.
H LiuDepartment of Oncology and Vascular Interventional Radiology, Zhongshan Hospital, Xiamen University, Xiamen, China.
Y ZhouDepartment of Oncology and Vascular Interventional Radiology, Zhongshan Hospital, Xiamen University, Xiamen, China.
W ChenDepartment of Oncology and Vascular Interventional Radiology, Zhongshan Hospital, Xiamen University, Xiamen, China.
X ZhangDepartment of Oncology and Vascular Interventional Radiology, Zhongshan Hospital, Xiamen University, Xiamen, China.
Y WangMedical Reproductive Auxiliary Specialty, People's Hospital of Jiuquan City, Gansu, China.
L XiaoDepartment of Oncology and Vascular Interventional Radiology, Zhongshan Hospital, Xiamen University, Xiamen, China.
Y ZhaoDepartment of Oncology and Vascular Interventional Radiology, Zhongshan Hospital, Xiamen University, Xiamen, China. zhaoboxmu@xmu.edu.cn.
Xiamen University · CNZhongshan Hospital of Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInguinal hernia often occurs in elderly men, and more than one in five men will undergo inguinal hernia repair during their lifetime. Nevertheless, the underlying molecular mechanisms of the pathogenesis behind hernia formation is still unclear. The aims in this study are finding out the potential gene markers and available drugs.

methodsFirstly, we re-analyzed the GSE92748 datasets, including four high and four low expressions of humanized aromatase transgenic mice, which refers to mimic humanized hernia, to identify differentially expressed genes (DEGs) in Arom

resultsWe have identified 64 DEGs, which were associated with muscle system process, actomyosin structure organization etc. Moreover, the significant module genes in PPI networks were Cmya1, Casq2, Cmya5, Ttn, Csrp3 and Actc1, and one existing drug, DEXAMETHASONE, have targeted to Actc1 gene.

conclusionsIn the paper, we identified 6 potential genes and one existing drug for inguinal hernia, which might be used as targets and drugs for the study of inguinal hernia.

Indexed as

Gene Expression ProfilingHernia, InguinalHumansBioinformaticsGenetic biomarkersInguinal herniaMimic hernia model

Identifiers

PMID32424728
OpenAlexW3027485411

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.